Department of Physical Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
Navigation and Accessibility Research Center of Ariel University (NARCA), Ariel University, Ariel, Israel.
PLoS One. 2023 Jan 11;18(1):e0272952. doi: 10.1371/journal.pone.0272952. eCollection 2023.
Parkinson's disease (PD) affects both men and women with documented gender differences across functional domains, with findings varying among reports. Knowledge regarding gender differences in PD for different geographic locations is important for further understanding of the disease and for developing personalized gender-specific PD assessment tools and therapies.
This study aimed to examine gender differences in PD-related motor, motor-cognitive, cognitive, and psychosocial function in people with PD from the southern United States (US).
199 (127 men and 72 women; M age: 69.08±8.94) individuals with mild-moderate idiopathic PD (Hoehn &Yahr (H&Y) Median = 2, stages I-III) from a large metro area in the southeastern US were included in this retrospective, cross-sectional study. Motor, motor-cognitive, cognitive, and psychosocial data were obtained using standardized and validated clinical tests. Univariate analyses were performed, adjusting for age and housing type.
After adjustment for age, housing, PD duration and fall rate, men exhibited statistically significantly greater motor (Movement Disorders Society (MDS)-Unified Parkinson Disease Rating Scale (UPDRS)-II) and non-motor (MDS-UPDRS-I) impact of PD, and more severe motor signs (MDS-UPDRS-III). Men exhibited worse PD-specific health-related quality of life related to mobility, activities of daily living, emotional well-being, cognitive impairment, communication, and more depressive symptoms. Men performed worse on a subtraction working memory task. Women had slower fast gait speed.
In the southeastern United States, men may experience worse PD-related quality of life and more depression than women. Many non-motor and motor variables that are not PD specific show no differences between genders in this cohort. These findings can contribute to the development of gender-sensitive assessment and rehabilitation policies and protocols for people with PD.
帕金森病（PD）影响男性和女性，其在不同功能领域存在明确的性别差异，不同报道中的发现也有所不同。了解不同地理位置 PD 患者的性别差异，对于进一步了解该疾病以及开发针对不同性别的个性化 PD 评估工具和治疗方法非常重要。
本研究旨在研究美国南部 PD 患者的运动、运动认知、认知和心理社会功能的性别差异。
本研究为回顾性、横断面研究，纳入了来自美国东南部一个大都市区的 199 名（127 名男性和 72 名女性；M 年龄：69.08±8.94）轻度至中度特发性 PD 患者（Hoehn & Yahr（H&Y）中位数=2，阶段 I-III）。使用标准化和验证过的临床测试获得运动、运动认知、认知和心理社会数据。进行了单变量分析，并调整了年龄和住房类型。
在调整年龄、住房、PD 持续时间和跌倒率后，男性的运动（运动障碍协会（MDS）-统一帕金森病评定量表（UPDRS）-II）和非运动（MDS-UPDRS-I）PD 影响以及更严重的运动体征（MDS-UPDRS-III）方面表现出统计学上显著更大的差异。男性的 PD 特定的与移动、日常生活活动、情绪健康、认知障碍、沟通和更多抑郁症状相关的健康相关生活质量更差。男性在减法工作记忆任务中的表现更差。女性的快速步态速度较慢。
在美国东南部，男性的 PD 相关生活质量和抑郁症状可能比女性更差。在本队列中，许多非运动和运动变量在性别之间没有差异，这些发现有助于制定针对 PD 患者的性别敏感评估和康复政策和方案。
