血管标志物CD31也能突出显示皮肤肿瘤内的组织细胞和组织细胞样细胞。
The vascular marker CD31 also highlights histiocytes and histiocyte-like cells within cutaneous tumors.
作者信息
Vanchinathan Vijay, Mirzamani Neda, Kantipudi Ramya, Schwartz Erich J, Sundram Uma N
机构信息
From the Departments of Pathology, Stanford University Medical Center, Stanford, CA.
From the Departments of Pathology, Stanford University Medical Center, Stanford, CA. From the Departments of Dermatology, Stanford University Medical Center, Stanford, CA.
出版信息
Am J Clin Pathol. 2015 Feb;143(2):177-85; quiz 305. doi: 10.1309/AJCPRHM8CZH5EMFD.
OBJECTIVES
While useful in diagnosing angiosarcomas, CD31 can also highlight histiocytes within soft tissue tumors and lead to errors in diagnosis. We sought to determine how often CD31 highlights cutaneous histiocytomas and histiocytoma mimics.
METHODS
We examined eight epithelioid cell histiocytomas (ECHs), 12 xanthogranulomas (XGs), nine cases of Langerhans cell histiocytosis (LCH), eight reticulohistiocytomas, 11 xanthomas, 29 atypical fibroxanthomas, nine granular cell tumors, four cases of angiolymphoid hyperplasia with eosinophilia, nine intradermal Spitz nevi, and nine angiosarcomas with antibodies directed against CD31, CD34, CD163, and factor VIII.
RESULTS
CD31 marked cells in three of 12 XGs, four of nine cases of LCH, one of eight reticulohistiocytomas, one of 11 xanthomas, 10 of 29 atypical fibroxanthomas, four of four cases of angiolymphoid hyperplasia with eosinophilia, nine of nine angiosarcomas, zero of nine granular cell tumors, and zero of eight ECHs. CD34 and factor VIII were negative in all nonvascular cases.
CONCLUSIONS
Our results indicate that CD31 can mark lesional cells and imitate vascular tumors in cutaneous histiocytomas and histiocytoma mimics, an error that can be avoided by using a panel of antibodies.
目的
CD31虽有助于诊断血管肉瘤，但也可使软组织肿瘤内的组织细胞显色，导致诊断错误。我们试图确定CD31使皮肤组织细胞瘤及组织细胞瘤样病变显色的频率。
方法
我们用抗CD31、CD34、CD163和因子VIII的抗体检测了8例上皮样细胞组织细胞瘤（ECH）、12例黄色肉芽肿（XG）、9例朗格汉斯细胞组织细胞增生症（LCH）、8例网状组织细胞瘤、11例黄瘤、29例非典型纤维黄色瘤、9例颗粒细胞瘤、4例伴有嗜酸性粒细胞增多的血管淋巴样增生、9例皮内斯皮茨痣和9例血管肉瘤。
结果
在12例XG中有3例、9例LCH中有4例、8例网状组织细胞瘤中有1例、11例黄瘤中有1例、29例非典型纤维黄色瘤中有10例、4例伴有嗜酸性粒细胞增多的血管淋巴样增生中有4例、9例血管肉瘤中有9例、9例颗粒细胞瘤中有0例、8例ECH中有0例的细胞被CD31标记。在所有非血管性病例中，CD34和因子VIII均为阴性。
结论
我们的结果表明，CD31可标记皮肤组织细胞瘤及组织细胞瘤样病变中的病变细胞并模仿血管肿瘤，通过使用一组抗体可避免这一错误。
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