Hyde P J, Tipper J, Fisher J, Hall R M
School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK (Until 30 Oct 2014).
School of Mechanical Engineering, Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK (Until 30 Oct 2014).
J Mech Behav Biomed Mater. 2015 Apr;44:43-52. doi: 10.1016/j.jmbbm.2014.12.001. Epub 2014 Dec 19.
Development of pre-clinical testing methodologies is an important goal for improving prediction of artificial replacement joint performance and for guiding future device design. Total disc replacement wear and the potential for osteolysis is a growing concern, therefore a parametric study on the effects on wear of altered kinematics and loading was undertaken. A standard ISO testing protocol was modified in order to study the wear behaviour of lumbar total disc replacements when subject to low cross shear input kinematics, reduced axial loading and smaller flexion-extension magnitude. Volumetric wear, bearing surface topography, and wear debris biological reactivity were assessed. The ISO standard results were expected, however, the very low cross shear test produced a level of wear approximately two orders of magnitude higher than that reported for zero cross shear motions on UHMWPE bearings. When the osteolytic potential of the wear particles was calculated, all total disc replacement simulations had lower predicted osteolytic potential compared to total hip replacements, as a consequence of the generally lower wear rates found.
临床前测试方法的开发是提高人工置换关节性能预测和指导未来器械设计的重要目标。全椎间盘置换的磨损以及骨溶解的可能性日益受到关注，因此开展了一项关于改变运动学和载荷对磨损影响的参数研究。对标准的ISO测试协议进行了修改，以研究腰椎全椎间盘置换在低交叉剪切输入运动学、降低轴向载荷和较小屈伸幅度情况下的磨损行为。评估了体积磨损、轴承表面形貌以及磨损颗粒的生物反应性。预期会得到ISO标准结果，然而，极低交叉剪切试验产生的磨损水平比报道的超高分子量聚乙烯（UHMWPE）轴承零交叉剪切运动的磨损水平高约两个数量级。当计算磨损颗粒的骨溶解潜力时，由于总体磨损率较低，所有全椎间盘置换模拟的预测骨溶解潜力均低于全髋关节置换。
