钯催化剂促进的邻位 C-H 胺化反应。
Ligand-promoted ortho-C-H amination with Pd catalysts.
机构信息
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
出版信息
Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2497-500. doi: 10.1002/anie.201408651. Epub 2015 Jan 16.
PMID:25598232
Abstract
2,4,6-Trimethoxypyridine is identified as an efficient ligand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzylamines. This finding provides guidance for the development of ligands that can improve or enable Pd(II)-catalyzed Csp2-H activation reactions directed by weakly coordinating functional groups.
摘要
2,4,6-三甲氧基吡啶被确定为一种有效的配体，可促进 Pd 催化的苯甲酰胺和三氟甲磺酸酯保护的苄胺的邻位 C-H 胺化反应。这一发现为开发配体提供了指导，这些配体可以改善或实现由弱配位官能团导向的 Pd(II)催化的 Csp2-H 活化反应。
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