非导向芳香碳氢键胺化反应：钯催化剂和试剂设计助力下的催化与机理研究
Non-directed aromatic C-H amination: catalytic and mechanistic studies enabled by Pd catalyst and reagent design.
作者信息
Bandara H M D, Jin D, Mantell M A, Field K D, Wang A, Narayanan R P, Deskins N A, Emmert M H
机构信息
Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
Department of Chemical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, USA.
出版信息
Catal Sci Technol. 2016 Jul 21;6(14):5304-5310. doi: 10.1039/C6CY00457A. Epub 2016 Mar 24.
Abstract
This manuscript describes the systematic development of pyridine-type ligands, which promote the Pd catalyzed, non-directed amination of benzene in combination with novel, hydroxylamine-based electrophilic amination reagents. DFT calculations and mechanistic experiments provide insights into the factors influencing the arene C-H amination protocol.
摘要
本手稿描述了吡啶型配体的系统开发，该配体与新型的基于羟胺的亲电胺化试剂相结合，促进钯催化的苯的非导向胺化反应。密度泛函理论计算和机理实验为影响芳烃C-H胺化反应的因素提供了见解。
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