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环橄榄脂素，一种从香樟根中提取的木脂素。

Cycloolivil, a lignan from the roots of Stereospermum suaveolens.

作者信息

Wahab Sab B Abdul, Jacob Janani, Manjunath Gururaja Giligar, Singh Vineet Kumar, Mundkinajeedu Deepak, Shankarappa Shashidhara

机构信息

Pharmacognosy, Government College of Pharmacy, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.

Department of Phytochemistry, Natural Remedies Pvt. Ltd. Bangalore, Karnataka, India.

出版信息

Pharmacognosy Res. 2015 Jan-Mar;7(1):45-8. doi: 10.4103/0974-8490.147198.

DOI:10.4103/0974-8490.147198
PMID:25598634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4285648/
Abstract

BACKGROUND

Stereospermum suaveolens DC. (Syn. S. chelonoides) belonging to family Bignoniaceae is an important medicinal plant in India. Traditionally, it is mainly used as analgesic, liver stimulant, astringent, wound healing and antidyspeptic. Roots of this plant are one of the ingredients of Dashamularishta. The plant has been studied for many pharmacological actions, only few were concerned with isolation of active compounds.

OBJECTIVE

The present work deals with the isolation and identification of phytochemical constituents present in the roots of Stereospermum suaveolens.

MATERIAL AND METHODS

The compounds were isolated from the ethyl acetate-soluble fraction from the methanol extract of S. suaveolens by using open silica gel column chromatography and HPLC was carried out for all the fractions to target the major peaks in fractions.

RESULTS AND CONCLUSION

The isolated compounds structures were elucidated by analysis of spectroscopic data (UV, IR, 1D-NMR, and MS) and characterized as Cycloolivil (1) reported for the first time from this plant species, Lapachol (2) and β-sitosterol (3), respectively.

摘要

背景

紫葳科植物羽叶楸（Stereospermum suaveolens DC.，异名S. chelonoides）是印度一种重要的药用植物。传统上，它主要用作镇痛药、肝脏兴奋剂、收敛剂、伤口愈合药和消化不良药。这种植物的根是十味药油（Dashamularishta）的成分之一。该植物已针对多种药理作用进行了研究，但只有少数研究涉及活性化合物的分离。

目的

本研究旨在对羽叶楸根中的植物化学成分进行分离和鉴定。

材料与方法

通过开放硅胶柱色谱法从羽叶楸甲醇提取物的乙酸乙酯可溶部分中分离化合物，并对所有部分进行高效液相色谱分析以确定各部分中的主要峰。

结果与结论

通过光谱数据（紫外、红外、一维核磁共振和质谱）分析阐明了分离出的化合物结构，分别鉴定为环橄榄脂素（1）（首次从该植物物种中报道）、拉帕醇（2）和β-谷甾醇（3）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/7ac1d716fee1/PR-7-45-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/024832fe8d87/PR-7-45-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/42032db27f87/PR-7-45-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/6ed974e84dba/PR-7-45-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/7ac1d716fee1/PR-7-45-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/024832fe8d87/PR-7-45-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/42032db27f87/PR-7-45-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/6ed974e84dba/PR-7-45-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af1f/4285648/7ac1d716fee1/PR-7-45-g004.jpg

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