急性淋巴细胞白血病患儿治疗后的牙齿异常与牙齿年龄评估
Dental anomalies and dental age assessment in treated children with acute lymphoblastic leukemia.
作者信息
Khojastepour L, Zareifar S, Ebrahimi M
机构信息
Department of Oral and Maxillofacial Radiology, Shiraz University of Medial Science, Shiraz, Iran.
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Iran J Ped Hematol Oncol. 2014;4(4):172-7. Epub 2014 Dec 10.
BACKGROUND
This cross sectional study was performed to evaluate dental ages and incidence of dental anomalies in children treated for acute lymphoblastic leukemia (ALL).
METHODS AND MATERIALS
A total of 25 ALL patient who passed at least 2 years of chemotherapy and 25 healthy sex and age matched children were evaluated. Dental age as well as dental anomalies in shape, size, number, and structure was recorded based on their panoramic radiographies which were taken for dental purposes.
RESULTS
The number of dental anomalies significantly increased in ALL treated children. Seven ALL cases (28%) in compression to only one (4%) in control group had at least one dental anomaly. However, there was neither statistically significant differences between the mean of dental (p=0.32) and chronologic age (p=0.12) in both groups, nor between dental age of cases and control group (p=0.62).The age at the onset of treatment as well as treatment durations has not affected dental age and the incidence of dental anomalies significantly (p<0.05).
CONCLUSION
Chemotherapy in children results in emergence of dental anomaly. Dental age, maturity, and development process however seems to be independent from chemotherapy.
背景
本横断面研究旨在评估接受急性淋巴细胞白血病（ALL）治疗的儿童的牙龄及牙齿异常的发生率。
方法和材料
共评估了25例至少经过2年化疗的ALL患者以及25例性别和年龄匹配的健康儿童。根据为牙科目的拍摄的全景X线片记录牙龄以及牙齿在形状、大小、数量和结构方面的异常情况。
结果
接受ALL治疗的儿童牙齿异常的数量显著增加。与对照组仅1例（4%）有至少1处牙齿异常相比，ALL组有7例（28%）。然而，两组的平均牙龄（p = 0.32）和实足年龄（p = 0.12）之间，以及病例组和对照组的牙龄之间均无统计学显著差异（p = 0.62）。治疗开始时的年龄以及治疗持续时间对牙龄和牙齿异常的发生率均无显著影响（p < 0.05）。
结论
儿童化疗会导致牙齿异常的出现。然而，牙龄、成熟度和发育过程似乎与化疗无关。
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