Goho C
Pediatric Dentistry, U.S. Army Dental Activity, Würzburg, Germany.
Pediatr Dent. 1993 Jan-Feb;15(1):6-12.
Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care. Defects noted include tooth and root agenesis, root thinning and shortening, and localized enamel defects. Histologically, these defects appear as osteoid-like niches in the developing dentin which alter the overlying enamel. Odontogenic cell sensitivity is dependent upon the position on the cell cycle and the mitotic activity at the time of chemoradiation therapy. Knowledge of the stage of dental development at the time of oncology treatment and the type of therapy allows the clinician to predict dental effects of the chemoradiation. Representative cases illustrate the clinical manifestations of chemoradiation on the developing dentition.
用于儿科肿瘤患者的放化疗常常会导致影响未来牙齿护理的牙齿发育异常。已发现的缺陷包括牙齿和牙根发育不全、牙根变细和缩短，以及局部釉质缺陷。从组织学上看，这些缺陷表现为发育中的牙本质中类骨样龛，从而改变覆盖其上的釉质。牙源性细胞的敏感性取决于细胞周期中的位置以及放化疗时的有丝分裂活性。了解肿瘤治疗时牙齿发育的阶段以及治疗类型，可使临床医生预测放化疗对牙齿的影响。代表性病例说明了放化疗对发育中牙列的临床表现。
