Si Jun-Kang, Tang Kai, Bi Hong-Sheng, Guo Da-Dong, Guo Jun-Guo, Wang Xing-Rong
*MD †PhD Department of Ophthalmology, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China (J-KS, KT); Department of Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China (H-SB, X-RW); and Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China (D-DG, J-GG).
Optom Vis Sci. 2015 Mar;92(3):252-7. doi: 10.1097/OPX.0000000000000505.
To conduct a meta-analysis on the effects of orthokeratology in slowing myopia progression.
A literature search was performed in PubMed, Embase, and the Cochrane Library. Methodological quality of the literature was evaluated according to the Jadad score. The statistical analysis was carried out using RevMan 5.2.6 software.
The present meta-analysis included seven studies (two randomized controlled trials and five nonrandomized controlled trials) with 435 subjects (orthokeratology group, 218; control group, 217) aged 6 to 16 years. The follow-up time was 2 years for the seven studies. The weighted mean difference was -0.26 mm (95% confidence interval, -0.31 to -0.21; p < 0.001) for axial length elongation based on data from seven studies and -0.18 mm (95% confidence interval, -0.33 to -0.03; p = 0.02) for vitreous chamber depth elongation based on data from two studies.
Our results suggest that orthokeratology may slow myopia progression in children. Further large-scale studies are needed to substantiate the current result and to investigate the long-term effects of orthokeratology in myopia control.
对角膜塑形术延缓近视进展的效果进行荟萃分析。
在PubMed、Embase和Cochrane图书馆进行文献检索。根据Jadad评分评估文献的方法学质量。使用RevMan 5.2.6软件进行统计分析。
本荟萃分析纳入了7项研究（2项随机对照试验和5项非随机对照试验），共435名6至16岁的受试者（角膜塑形术组218名；对照组217名）。这7项研究的随访时间均为2年。基于7项研究的数据，眼轴长度伸长的加权平均差为-0.26毫米（95%置信区间，-0.31至-0.21；p<0.001）；基于2项研究的数据，玻璃体腔深度伸长的加权平均差为-0.18毫米（95%置信区间，-0.33至-0.03；p = 0.02）。
我们的结果表明，角膜塑形术可能会减缓儿童近视的进展。需要进一步开展大规模研究来证实目前的结果，并调查角膜塑形术在控制近视方面的长期效果。
