Aier Eye Hospital of Wuhan University, Wuhan, China.
Medicine (Baltimore). 2022 Aug 19;101(33):e30178. doi: 10.1097/MD.0000000000030178.
The purpose of the study was to conduct a meta-analysis about the effect of the combined application of orthokeratology and single-vision spectacles on slowing the progression of high myopia.
The literature was searched in PubMed, EMBASE, the Cochrane Library, Wang Fang Data, CNKI and sinoMed. The Cochrane Handbook was used to evaluate the quality of the included randomized clinical trials, and the Newcastle-Ottawa Scale was used to evaluate the included case-control or cohort studies. The results were analyzed by Revman 5.3.
Five studies (2 randomized clinical trials, 2 case-controls, and 1 cohort study) with a total of 360 patients were included in this meta-analysis. The follow-up time was at least 1 year. Combined application of orthokeratology and single-vision spectacles were used in the experimental group. The control group used single-vision spectacles only. The pooled estimates indicated that the standardized mean difference between the 2 groups was -1.46 mm (95% confidence interval: -1.88 to -1.05; P < .05) for axial length elongation and -1.85D (95% confidence interval: -2.40 to -1.31; P < .05) for change in spherical equivalent refraction. No serious adverse events were reported in all studies.
The combined application of orthokeratology and single-vision spectacles is more effective than single-vision spectacles only on slowing the progression of high myopia.
本研究旨在进行荟萃分析，评估角膜塑形术联合单焦眼镜对减缓高度近视进展的效果。
检索 PubMed、EMBASE、Cochrane 图书馆、万方数据、中国知网和中国生物医学文献服务系统。采用 Cochrane 手册评价纳入的随机临床试验的质量，采用 Newcastle-Ottawa 量表评价纳入的病例对照或队列研究的质量。采用 Revman 5.3 进行数据分析。
本荟萃分析纳入了 5 项研究（2 项随机临床试验、2 项病例对照研究和 1 项队列研究），共 360 例患者。随访时间至少 1 年。实验组采用角膜塑形术联合单焦眼镜，对照组仅使用单焦眼镜。汇总估计值表明，2 组间眼轴延长的标准化均数差为-1.46 mm（95%置信区间：-1.88 至-1.05；P <.05），等效球镜屈光度变化的标准化均数差为-1.85D（95%置信区间：-2.40 至-1.31；P <.05）。所有研究均未报告严重不良事件。
与单纯使用单焦眼镜相比，角膜塑形术联合单焦眼镜更能有效减缓高度近视的进展。
