Cirad, UMR Biologie et Génétique des Interactions Plante-Parasite, Montpellier, France.
Institut für Chemie, Technische Universität Berlin, Berlin, Germany.
Nat Chem Biol. 2015 Mar;11(3):195-7. doi: 10.1038/nchembio.1734. Epub 2015 Jan 19.
Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
阿泊西林是由甘蔗致病菌黄单胞菌属产生的一种强效 DNA 拓扑异构酶抑制剂。本文报道了阿泊西林结构的首次阐明，揭示了一种独特的多芳香族寡肽，主要由对氨基苯甲酸组成。体外研究进一步揭示了阿泊西林的生物合成机制。这些发现将有助于研究阿泊西林的抑制机制，并评估其作为一种高效抗菌药物的潜力。
