Jiang Benchun, Zhu Ke, Shao Hua, Bao Chenhui, Ou Jinlei, Sun Wei
Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning, China.
Sci Rep. 2015 Jan 20;5:7891. doi: 10.1038/srep07891.
E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in increased susceptibility to tumor development and subsequent tumor cell invasion and metastasis. The CDH1 C-160A polymorphism could decrease its transcription efficiency and may increase susceptibility to cancer development, but its relevance to gastric cancer is generally disputed. Consequently, we performed a meta-analysis of published case-control studies, including 4218 gastric cancer cases and 5461 controls. Overall, no significant association was observed between the CDH1 C-160A polymorphism and risk of gastric cancer in all genetic models. In the stratified analysis by total sample size, a significant association was observed in the small sample size subgroup (total sample size < 300), but the results should be interpreted with caution. In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer. Large-scale and well-designed studies are needed to confirm our findings.
E-钙黏蛋白（CDH1）在细胞黏附中起关键作用，这对细胞的正常发育和维持至关重要。CDH1的下调可能导致细胞间黏附系统功能障碍，从而增加肿瘤发生以及随后肿瘤细胞侵袭和转移的易感性。CDH1 C-160A多态性可能会降低其转录效率，并可能增加患癌易感性，但其与胃癌的相关性普遍存在争议。因此，我们对已发表的病例对照研究进行了荟萃分析，其中包括4218例胃癌病例和5461例对照。总体而言，在所有遗传模型中，未观察到CDH1 C-160A多态性与胃癌风险之间存在显著关联。在按总样本量进行的分层分析中，在小样本量亚组（总样本量<300）中观察到显著关联，但对结果的解释应谨慎。总之，这项荟萃分析未能证实CDH1 C-160A多态性与胃癌风险之间的关联。需要大规模且设计良好的研究来证实我们的发现。
