Burzotta Francesco, Dato Ilaria, Trani Carlo, Pirozzolo Giancarlo, De Maria Giovanni Luigi, Porto Italo, Niccoli Giampaolo, Leone Antonio Maria, Schiavoni Giovanni, Crea Filippo
Cardiovascular Science Department, Catholic University of the Sacred Heart, Rome, Italy.
EuroIntervention. 2015 Jan;10(9):e1-8. doi: 10.4244/EIJV10I9A179.
The aim of this study was to assess the feasibility of unprotected non-ostial left main (LM) imaging by frequency domain optical coherence tomography (FD-OCT).
We conducted a retrospective analysis of OCT studies performed to image lesions located in the non-ostial LM. OCT studies were analysed off-line to detect the number of artefact frames in the different LM/bifurcation segments. OCT cross-sectional images were used to assess area measures. OCT longitudinal reconstructions were used to obtain the LM length. Standard quantitative coronary angiography (QCA) was used as the reference methodology. A total of 54 patients with non-ostial LM disease entered the study. The mean number of LM artefact frames was 8±10, corresponding to 19% of the total number of LM frames analysed. The percentages of artefact frames differed significantly according to the segment analysed: 43.3% proximal LM, 11.4% mid LM and 2.1% distal LM, 2.0% ostial left anterior descending artery and 0% ostial left circumflex artery (p<0.0001). All LM OCT measurements were significantly correlated with QCA measurements.
The results of the present study show that FD-OCT assessment of non-ostial LM disease is feasible and may provide high-quality imaging. OCT assessment of distal LM is more efficient than that of the proximal LM segment.
本研究旨在评估频域光学相干断层扫描（FD-OCT）对非开口处左主干（LM）进行无保护成像的可行性。
我们对为非开口处LM病变成像而进行的OCT研究进行了回顾性分析。对OCT研究进行离线分析，以检测不同LM/分叉节段中的伪影帧数。OCT横断面图像用于评估面积测量值。OCT纵向重建用于获取LM长度。标准定量冠状动脉造影（QCA）用作参考方法。共有54例非开口处LM疾病患者进入研究。LM伪影帧的平均数量为8±10，占分析的LM帧总数的19%。根据分析的节段不同，伪影帧的百分比差异显著：LM近端为43.3%，LM中段为11.4%，LM远端为2.1%，左前降支开口处为2.0%，左旋支开口处为0%（p<0.0001）。所有LM的OCT测量值与QCA测量值均显著相关。
本研究结果表明，FD-OCT评估非开口处LM疾病是可行的，并且可能提供高质量成像。OCT评估LM远端比评估LM近端节段更有效。
