Ardalan Mohammad Reza, Khodaie Laleh, Nasri Hamid, Jouyban Abolghasem
Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Kidney Dis. 2015 Jan;9(1):14-7.
Herbs are usually considered as inherently harmless products. Nonetheless, various renal injuries have been reported in association with several herbs. The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid is found in Chinese slim herbs. Balkan endemic nephropathy is nowadays considered as an aristolochic acid nephropathy. Plants of Aristolochiaceae (also known as birthwort, dutchman's pipe, and somersworth) is named zaravand or chopoghak in Persian and it grows in different mountainous and rural areas of Iran. The fruit and the steam of the Aristolochiacae are named zaravand gerd (nokhod alvand) and zaravand dearaz, respectively, and have different usage in Iranian teadirional such as treatment of headache, back pain, and anxiety. Some patients with end-stage renal disease and bilateral small kidneys have a history of exposure to some herbal remedies. We need to consider the possibility of environmental toxins and even Aristolochia nephrotoxicity as a potential danger in Iran.
草药通常被认为是本质上无害的产品。尽管如此，已有多种与草药相关的肾脏损伤报告。最著名的草药引起的慢性肾脏病是马兜铃酸肾病。马兜铃酸存在于中药细梗香草中。巴尔干地方性肾病如今被认为是一种马兜铃酸肾病。马兜铃科植物（也称为马兜铃、烟斗花和索默斯沃思）在波斯语中名为zaravand或chopoghak，生长在伊朗不同的山区和乡村地区。马兜铃科的果实和茎分别名为zaravand gerd（nokhod alvand）和zaravand dearaz，在伊朗传统医学中有不同用途，如治疗头痛、背痛和焦虑。一些终末期肾病和双侧小肾脏患者有接触某些草药疗法的病史。在伊朗，我们需要考虑环境毒素甚至马兜铃肾毒性作为潜在危险的可能性。
