Arat Nurcan, Kaçar Sabite, Gölbaşı Zehra, Akdoğan Meral, Kuran Sedef
Department of Cardiology, İstanbul Bilim University Faculty of Medicine, İstanbul, Turkey.
Turk J Gastroenterol. 2014 Dec;25(6):678-84. doi: 10.5152/tjg.2014.5949.
BACKGROUND/AIMS: Videodensitometry is a feasible noninvasive ultrasound tissue characterization method allowing early detection of myocardial changes. This study aimed to investigate ultrasonic backscatter properties of the myocardium in Wilson disease patients.
We compared cardiologically asymptomatic Wilson disease patients (W group) (n=18) with age-matched (26.7±9.6 years) healthy controls (C group) (n=15). Diagnosis of Wilson disease was made on the basis of clinical manifestations, family history, and laboratory findings and confirmed by liver biopsy. Transthoracic echocardiographic quantitative texture analysis was performed on data from the septum and left ventricular posterior wall, and mean gray level (MGL) histograms at end-diastole (d) and end-systole (s) were obtained after background correction (c). Cyclic variation index (CVI) was calculated using the formula [(cMGLd - cMGLs) / cMGLd] ×100.
There were no significant differences in sex, age, body mass index, heart rate or blood pressure, and conventional echocardiographic parameters between the 2 groups. The cMGLs value of the posterior wall was higher in the W group than in the C group (30.9±2.6 vs. 22.2±2.7, p=0.033). The W group had a significantly lower CVI of the septum than did the C group (-22±4.4% vs. 43.4 ±12.9%, p<0.001), and there was no significant difference in the CVI of the posterior wall (-67.0±15.9% vs. 41.7±18.6%, p=0.32).
Abnormalities in two-dimensional echocardiographic grey-level distributions were present in Wilson disease patients. These videodensitometric myocardial alterations were significantly lower in Wilson disease patients than in the controls, and this probably represents an early stage of cardiac involvement.
背景/目的：视频密度测定法是一种可行的非侵入性超声组织特征分析方法，可早期检测心肌变化。本研究旨在调查威尔逊病患者心肌的超声背向散射特性。
我们将心脏无症状的威尔逊病患者（W组）（n = 18）与年龄匹配（26.7±9.6岁）的健康对照者（C组）（n = 15）进行比较。威尔逊病的诊断基于临床表现、家族史和实验室检查结果，并经肝活检证实。对来自室间隔和左心室后壁的数据进行经胸超声心动图定量纹理分析，在背景校正（c）后获得舒张末期（d）和收缩末期（s）的平均灰度（MGL）直方图。使用公式[（cMGLd - cMGLs）/ cMGLd]×100计算周期性变化指数（CVI）。
两组在性别、年龄、体重指数、心率或血压以及传统超声心动图参数方面无显著差异。W组后壁的cMGLs值高于C组（30.9±2.6对22.2±2.7，p = 0.033）。W组室间隔的CVI显著低于C组（-22±4.4%对43.4±12.9%，p<0.001），后壁的CVI无显著差异（-67.0±15.9%对41.7±18.6%，p = 0.32）。
威尔逊病患者存在二维超声心动图灰度分布异常。这些视频密度测定的心肌改变在威尔逊病患者中明显低于对照组，这可能代表心脏受累的早期阶段。
