Department of Ophthalmology, Los Angeles County - University of Southern California Medical Center, Los Angeles, California.
Department of Pathology, Keck Medical Center of the University of Southern California, Los Angeles, California.
Ophthalmology. 2015 May;122(5):918-24. doi: 10.1016/j.ophtha.2014.11.027. Epub 2015 Jan 15.
To evaluate the spectrum and antibiotic susceptibility panel of infectious keratitis at a major tertiary care referral eye center and a major county hospital in Southern California.
Retrospective case series.
All cultured infectious keratitis cases from July 1, 2008, through December 31, 2012, from the Doheny Eye Institute (DEI) and the Los Angeles County + University of Southern California Medical Center (LAC+USC) were evaluated.
Microbiology records were reviewed retrospectively.
Microbial isolates as well as antibiotic susceptibility patterns were analyzed.
One hundred eighty-four (63%) of 290 cases showed positive culture results at DEI and 152 (82%) of 186 cases showed positive culture results at LAC+USC. Gram-positive pathogens were found to be the most common at both DEI (70%) and LAC+USC (68%), with coagulase-negative Staphylococcus being the most common gram-positive organism (58% at DEI and 44% at LAC+USC). Pseudomonas aeruginosa was the most common gram-negative organism (57% at DEI and 43% at LAC+USC). Ciprofloxacin and levofloxacin susceptibility for all tested pathogens was 73% at DEI and 81% at LAC+USC (P = 0.16). Oxacillin-resistant Staphylococcus aureus (ORSA) was found in 42% of cases at DEI and in 45% of cases at LAC+USC (P = 1.00).
There is no significant difference in the spectrum of pathogens or antibiotic susceptibility of pathogens at DEI versus LAC+USC, and ORSA was found in approximately half of all S. aureus samples.
评估南加州一家主要的三级转诊眼科中心和一家主要县医院的传染性角膜炎的光谱和抗生素药敏谱。
回顾性病例系列。
评估了 2008 年 7 月 1 日至 2012 年 12 月 31 日期间，来自多尼眼科研究所（DEI）和洛杉矶县+南加州大学医学中心（LAC+USC）的所有培养的传染性角膜炎病例。
回顾性审查微生物学记录。
分析微生物分离株和抗生素敏感性模式。
在 DEI 处，184 例（63％）的 290 例病例显示阳性培养结果，在 LAC+USC 处，152 例（82％）的 186 例病例显示阳性培养结果。在 DEI（70％）和 LAC+USC（68％）中，革兰氏阳性病原体被发现是最常见的病原体，凝固酶阴性葡萄球菌是最常见的革兰氏阳性菌（58％在 DEI 和 44％在 LAC+USC）。铜绿假单胞菌是最常见的革兰氏阴性菌（57％在 DEI 和 43％在 LAC+USC）。在所有测试的病原体中，环丙沙星和左氧氟沙星的敏感性在 DEI 为 73％，在 LAC+USC 为 81％（P=0.16）。在 DEI 中发现 42％的病例存在耐甲氧西林金黄色葡萄球菌（ORSA），在 LAC+USC 中发现 45％的病例存在 ORSA（P=1.00）。
在 DEI 与 LAC+USC 之间，病原体的光谱或病原体的抗生素敏感性没有明显差异，并且大约一半的金黄色葡萄球菌样本中存在 ORSA。
