通过羊水白细胞介素-8水平准确预测分娩前组织学绒毛膜羊膜炎的阶段
Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL-8 Level.
作者信息
Yoneda Satoshi, Shiozaki Arihiro, Ito Mika, Yoneda Noriko, Inada Kumiko, Yonezawa Rika, Kigawa Mika, Saito Shigeru
机构信息
Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
Department of Public Health Faculty of Medicine, University of Toyama, Toyama, Japan.
出版信息
Am J Reprod Immunol. 2015 Jun;73(6):568-76. doi: 10.1111/aji.12360. Epub 2015 Jan 20.
OBJECTIVE
To estimate the stage of histological chorioamnionitis (h-CAM) antenatally using clinical data.
MATERIALS AND METHODS
Four hundred and twenty-eight singleton mothers were recruited. Clinical data including the levels of white blood cell count (WBC), C-reactive protein (CRP), amniotic fluid interleukin-8 (AF-IL-8) at Cesarean section, and maternal body temperature (MBT) were collected.
RESULTS
Histological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h-CAM stage III. AF-IL-8 (odds ratio: 8.5, 95% CI: 5.1-14.8, P < 0.0001) and MBT (odds ratio: 2.3, 95% CI: 1.13-4.1, P = 0.0192) were independent risk factors for h-CAM. The cutoff value of AF-IL-8 for predicting each stage of h-CAM (stage I or higher, stage II or higher, and stage III) were ≥9.9 ng/mL, ≥17.3 ng/mL, and ≥55.9 ng/mL, respectively.
CONCLUSION
The stage of h-CAM was able to be predicted accurately by the level of AF-IL-8 before delivery.
目的
利用临床数据在产前评估组织学绒毛膜羊膜炎（h-CAM）的分期。
材料与方法
招募了428名单胎母亲。收集了剖宫产时的临床数据，包括白细胞计数（WBC）、C反应蛋白（CRP）、羊水白细胞介素-8（AF-IL-8）水平以及母体体温（MBT）。
结果
45.3%的病例存在组织学绒毛膜羊膜炎。h-CAM III期病例的新生儿预后不良率最高（59.1%）。AF-IL-8（比值比：8.5，95%置信区间：5.1-14.8，P<0.0001）和MBT（比值比：2.3，95%置信区间：1.13-4.1，P = 0.0192）是h-CAM的独立危险因素。预测h-CAM各期（I期及以上、II期及以上和III期）的AF-IL-8临界值分别为≥9.9 ng/mL、≥17.3 ng/mL和≥55.9 ng/mL。
结论
分娩前AF-IL-8水平能够准确预测h-CAM的分期。
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