溴夫定治疗异基因造血干细胞移植后多瘤病毒相关性肾病
Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation.
作者信息
Papanicolaou Genovefa A, Lee Yeon Joo, Young James W, Seshan Surya V, Boruchov Adam M, Chittick Gregory, Momméja-Marin Herve, Glezerman Ilya G
机构信息
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
出版信息
Am J Kidney Dis. 2015 May;65(5):780-4. doi: 10.1053/j.ajkd.2014.11.020. Epub 2015 Jan 17.
Abstract
Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment.
摘要
多瘤病毒相关性肾病（PVAN）在接受肾移植的患者中很常见，并且在造血干细胞（HSC）移植受者中也有报道。除了减少免疫抑制外，治疗PVAN的治疗选择很少。我们报告了一例严重免疫功能低下的异基因HSC移植受者发生PVAN，该患者接受了布林西多福韦治疗，且未减少免疫抑制。我们回顾了我们机构在HSC移植中PVAN的经验，并讨论了布林西多福韦治疗的潜在用途。
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