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异基因造血细胞移植后 BK 病毒相关性肾病的评估和管理。

Evaluation and management of BK virus-associated nephropathy following allogeneic hematopoietic cell transplantation.

机构信息

Department of Internal Medicine, University of North Dakota, ND, USA.

出版信息

Biol Blood Marrow Transplant. 2011 Nov;17(11):1589-93. doi: 10.1016/j.bbmt.2011.07.010. Epub 2011 Jul 20.

DOI:10.1016/j.bbmt.2011.07.010
PMID:21767514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4477525/
Abstract

BK virus nephropathy is a common cause of graft loss in kidney transplant recipients. Cases of BK nephropathy following allogeneic hematopoietic cell transplantation (HCT) are underreported. An increased incidence of BK virus-associated nephropathy is being seen in the setting of more profound and prolonged immunosuppression following solid organ transplantation and HCT. We will review diagnostic and treatment modalities for BK-associated nephropathy following allogeneic HCT.

摘要

BK 病毒肾病是肾移植受者移植物丢失的常见原因。异基因造血细胞移植 (HCT) 后发生 BK 肾病的病例报道较少。在实体器官移植和 HCT 后更深度和更长期的免疫抑制背景下，BK 病毒相关性肾病的发生率增加。我们将回顾异基因 HCT 后 BK 相关肾病的诊断和治疗方法。

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Biol Blood Marrow Transplant. 2011 Nov;17(11):1589-93. doi: 10.1016/j.bbmt.2011.07.010. Epub 2011 Jul 20.
2
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本文引用的文献

1
Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation.血液，而非尿液，BK 病毒载量可预测造血干细胞移植后发生出血性膀胱炎的儿童的肾脏结局。
Biol Blood Marrow Transplant. 2011 Oct;17(10):1512-9. doi: 10.1016/j.bbmt.2011.02.012. Epub 2011 Mar 6.
2
Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells.不同结构类型无环核苷膦酸酯类化合物对人原代肾细胞中 BK 病毒的作用。
Antimicrob Agents Chemother. 2011 May;55(5):1961-7. doi: 10.1128/AAC.01809-10. Epub 2011 Feb 22.
3
Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type.异基因造血干细胞移植后发生出血性膀胱炎是 BK 病毒感染、预处理方案强度和供者类型等多种因素复杂作用的结果。
Haematologica. 2010 Jul;95(7):1183-90. doi: 10.3324/haematol.2009.016758. Epub 2010 Apr 21.
4
Treatment of polyomavirus infection in kidney transplant recipients: a systematic review.肾移植受者多瘤病毒感染的治疗：系统评价。
Transplantation. 2010 May 15;89(9):1057-70. doi: 10.1097/TP.0b013e3181d0e15e.
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Leflunomide inhibition of BK virus replication in renal tubular epithelial cells.来氟米特抑制肾小管上皮细胞中 BK 病毒的复制。
J Virol. 2010 Feb;84(4):2150-6. doi: 10.1128/JVI.01737-09. Epub 2009 Dec 2.
6
Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs.免疫抑制药物对多瘤病毒 BK 特异性 T 细胞反应的抑制作用。
Transplantation. 2009 Nov 27;88(10):1161-8. doi: 10.1097/TP.0b013e3181bca422.
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Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host.对树突状细胞进行核转染以产生多病毒特异性T细胞，用于预防或治疗免疫功能低下宿主中的病毒感染。
Mol Ther. 2009 Sep;17(9):1616-25. doi: 10.1038/mt.2009.140. Epub 2009 Jul 7.
8
BK virus nephropathy after allogeneic stem cell transplantation: a case report and literature review.异基因造血干细胞移植后BK病毒肾病：一例报告及文献复习
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9
Antiviral therapy for polyomavirus-associated nephropathy after renal transplantation.肾移植后多瘤病毒相关性肾病的抗病毒治疗
J Antimicrob Chemother. 2008 Nov;62(5):855-9. doi: 10.1093/jac/dkn305. Epub 2008 Jul 25.
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Bone Marrow Transplant. 2008 Jan;41(1):11-8. doi: 10.1038/sj.bmt.1705886. Epub 2007 Oct 22.