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Plasma concentrations of 15-keto-13,14-dihydro-PGF-2 alpha, oestrone sulphate, oestradiol-17 beta and progesterone in pregnant guinea-pigs treated with polychlorinated biphenyls.

作者信息

Lundkvist U, Kindahl H

机构信息

Department of Zoophysiology, Uppsala University, Sweden.

出版信息

J Reprod Fertil. 1989 Sep;87(1):55-62. doi: 10.1530/jrf.0.0870055.

DOI:10.1530/jrf.0.0870055
PMID:2560062
Abstract

Guinea-pigs treated by gavage with a total dose of 100 mg polychlorinated biphenyls (PCB: Clophen A50) during Days 17-61 of gestation had higher plasma concentrations of 15-keto-13,14-dihydroprostaglandin F-2 alpha, oestrone sulphate and oestradiol-17 beta during the later stages of gestation than did vehicle-treated guinea-pigs. No changes were observed in plasma progesterone concentrations. Our results provide no support for the hypothesis that an enzyme-induced decrease in progesterone concentrations is the main cause of the fetal death observed in PCB-treated guinea-pigs.

摘要

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