Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Parasite Immunol. 2015 Jun;37(6):277-92. doi: 10.1111/pim.12175.
Some helminths are major human pathogens. Recently, however, increased understanding of the immunoregulatory responses induced by this class of parasites, in combination with epidemiologic and animal studies, suggests that helminths may have therapeutic potential in autoimmune diseases (AD) and other conditions. This article reviews the rationale for and results of clinical trials to test the safety and efficacy of helminth therapy in AD. Also discussed are future prospects for investigation and the possibility that helminth treatment may serve as a probe to help reveal the pathogenesis of AD.
一些寄生虫是主要的人类病原体。然而，最近对这类寄生虫引起的免疫调节反应的认识不断提高，再加上流行病学和动物研究，表明寄生虫可能在自身免疫性疾病 (AD) 和其他疾病中有治疗潜力。本文综述了临床试验的原理和结果，以测试寄生虫治疗在 AD 中的安全性和疗效。还讨论了未来的研究前景和寄生虫治疗可能作为一种探针来帮助揭示 AD 发病机制的可能性。
