Asan Memorial College of Engineering and Technology, Chengalpattu 603 105, Tamil Nadu, India.
Research Institute of Electronics, Shizuoka University, 3-5-1, Johoku, Naka-ku, Hamamatsu, Shizuoka 432-8011, Japan.
Colloids Surf B Biointerfaces. 2015 Feb 1;126:407-13. doi: 10.1016/j.colsurfb.2014.12.044. Epub 2015 Jan 3.
CdS nanoparticles are one among the most promising agents for fluorescent imaging. Hence, it is essential to develop new strategies to overcome the cytotoxicity of these nanoparticles. Surface modification is one of the simplest and effective techniques. This paper assesses the effect of surface modification on toxicity of the CdS nanoparticles. Unmodified CdS and surface-modified CdS nanoparticles were synthesized in an aqueous medium using a wet chemical route at room temperature. The surface modification of the CdS nanoparticles with polyvinylpyrrolidone (PVP) and cysteine was confirmed using infrared absorption studies. The diameters of unmodified CdS, PVP-modified CdS, and cysteine-modified CdS nanoparticles were determined using HRTEM. They exhibited luminescence in the range from 500 to 800 nm. The cytotoxic effects of these CdS nanoparticles were investigated in cultures of Vero cells. The results indicated that Vero cell viability was higher for the surface-modified CdS nanoparticles than for the unmodified CdS nanoparticles. The reduction in the toxicity was related to the nature of the capping agents used for the surface modification, and the particle size.
CdS 纳米粒子是最有前途的荧光成像试剂之一。因此，开发新的策略来克服这些纳米粒子的细胞毒性是至关重要的。表面修饰是最简单和最有效的技术之一。本文评估了表面修饰对 CdS 纳米粒子毒性的影响。未修饰的 CdS 和表面修饰的 CdS 纳米粒子在室温下通过水相化学法在水溶液中合成。通过红外吸收研究证实了 CdS 纳米粒子与聚乙烯吡咯烷酮（PVP）和半胱氨酸的表面修饰。使用 HRTEM 确定了未修饰的 CdS、PVP 修饰的 CdS 和半胱氨酸修饰的 CdS 纳米粒子的直径。它们在 500 到 800nm 的范围内表现出发光。这些 CdS 纳米粒子的细胞毒性在 Vero 细胞培养中进行了研究。结果表明，表面修饰的 CdS 纳米粒子对 Vero 细胞的存活率高于未修饰的 CdS 纳米粒子。毒性的降低与用于表面修饰的封端剂的性质和粒径有关。
