Munari Marco, Sturve Joachim, Frenzilli Giada, Sanders Matthew B, Brunelli Andrea, Marcomini Antonio, Nigro Marco, Lyons Brett P
Department of Biology, University of Padua, Padua, Italy.
Department of Biological and Environmental Sciences, University of Gothenburg, Göteborg, Sweden.
Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:89-93. doi: 10.1016/j.mrgentox.2014.09.003. Epub 2014 Sep 16.
The increasing use of nanotechnologies will lead to significant releases of engineered nanoparticles into the aquatic environment, where their impact is still poorly characterized. In the present paper, the genotoxic and cytotoxic properties of CdS quantum dots (QDs) and silver sulphide (Ag2S) coated with methyl polyethylene glycol (M-PEG) were investigated in a rainbow trout cell line (RTG-2). The results showed that CdS QDs were highly cytotoxic at high concentrations (10 and 50μg/ml), and exhibited a concentration-dependent genotoxicity in the sub-toxic range (0.01-1μg/ml) after 24h exposure. Ag2S showed neither genotoxic nor cytotoxic effects.
纳米技术的日益广泛应用将导致大量工程纳米颗粒释放到水生环境中，而其在该环境中的影响仍未得到充分表征。在本文中，我们研究了甲基聚乙二醇（M-PEG）包覆的硫化镉量子点（QDs）和硫化银（Ag2S）在虹鳟鱼细胞系（RTG-2）中的遗传毒性和细胞毒性特性。结果表明，硫化镉量子点在高浓度（10和50μg/ml）时具有高度细胞毒性，并且在暴露24小时后，在亚毒性范围（0.01-1μg/ml）内表现出浓度依赖性遗传毒性。硫化银既没有遗传毒性也没有细胞毒性作用。
