Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Kantstrasse 55, 14513, Teltow, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Augustenburger Platz 1, 13533 Berlin and Kantstr. 55, 14513, Teltow, Germany.
Adv Mater. 2015 Mar 11;27(10):1738-44. doi: 10.1002/adma.201404787. Epub 2015 Jan 20.
Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.
一步法即可制备出具有形态稳定性和弹性特性且可单独在不同长度尺度上进行调节的结构水凝胶。它们支持细胞黏附和分化，并在降解过程中呈现出不断增大的孔径。体内实验表明，它们在生物材料诱导的骨再生方面具有良好的效果，无需添加细胞或生长因子。
