将个性化医疗纳入医疗保健的伦理、法律和社会影响。
Ethical, legal and social implications of incorporating personalized medicine into healthcare.
作者信息
Brothers Kyle B, Rothstein Mark A
机构信息
Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, 231 East Chestnut Street, N-97, Louisville, KY 40202, USA ; Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA ; Institute for Bioethics, Health Policy & Law, University of Louisville School of Medicine, Louisville, KY, USA.
Institute for Bioethics, Health Policy & Law, University of Louisville School of Medicine, Louisville, KY, USA ; Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
出版信息
Per Med. 2015;12(1):43-51. doi: 10.2217/pme.14.65.
Abstract
As research focused on personalized medicine has developed over the past decade, bioethics scholars have contemplated the ethical, legal and social implications of this type of research. In the next decade, there will be a need to broaden the focus of this work as personalized medicine moves into clinical settings. We consider two broad issues that will grow in importance and urgency. First, we analyze the consequences of the significant increase in health information that will be brought about by personalized medicine. Second, we raise concerns about the potential of personalized medicine to exacerbate existing disparities in healthcare.
摘要
在过去十年中，随着聚焦于个性化医疗的研究不断发展，生物伦理学者一直在思考这类研究的伦理、法律和社会影响。在接下来的十年里，随着个性化医疗进入临床环境，有必要拓宽这项工作的重点。我们考虑两个将变得更加重要和紧迫的广泛问题。首先，我们分析个性化医疗将带来的健康信息大幅增加的后果。其次，我们对个性化医疗加剧现有医疗保健差距的可能性表示担忧。
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本文引用的文献
1
Autonomy and paternalism in health policy: currents in contemporary bioethics.卫生政策中的自主性与家长主义：当代生物伦理学思潮
J Law Med Ethics. 2014 Winter;42(4):590-4. doi: 10.1111/jlme.12178.
2
Socioeconomic inequalities in health after age 50: are health risk behaviors to blame?50 岁后健康的社会经济不平等：健康风险行为是否应该受到指责？
Soc Sci Med. 2014 Jan;101:52-60. doi: 10.1016/j.socscimed.2013.10.040. Epub 2013 Nov 16.
3
How could disclosing incidental information from whole-genome sequencing affect patient behavior?披露全基因组测序中的偶然信息会如何影响患者的行为？
Per Med. 2013 Jun;10(4). doi: 10.2217/pme.13.24.
4
Personalized medicine and genetic malpractice.个性化医疗与基因医疗事故
Genet Med. 2013 Dec;15(12):921-2. doi: 10.1038/gim.2013.142. Epub 2013 Sep 26.
5
Recommendations for returning genomic incidental findings? We need to talk!关于如何报告基因组偶然发现的建议？我们需要谈谈！
Genet Med. 2013 Nov;15(11):854-9. doi: 10.1038/gim.2013.113. Epub 2013 Aug 1.
6
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.ACMG 临床外显子组和基因组测序中偶然发现报告的推荐标准。
Genet Med. 2013 Jul;15(7):565-74. doi: 10.1038/gim.2013.73. Epub 2013 Jun 20.
7
What's so meaningful about meaningful use?有意义使用的意义何在？
Hastings Cent Rep. 2013 Mar-Apr;43(2):15-7. doi: 10.1002/hast.154.
8
Personalized genomic medicine and the rhetoric of empowerment.个体化基因组医学与赋权话语。
Hastings Cent Rep. 2012 Sep-Oct;42(5):34-40. doi: 10.1002/hast.65.
9
Currents in contemporary bioethics. Access to sensitive information in segmented electronic health records.当代生物伦理学中的热点问题。分段电子健康记录中敏感信息的获取。
J Law Med Ethics. 2012 Summer;40(2):394-400. doi: 10.1111/j.1748-720X.2012.00673.x.
10
Personalized medicine and access to health care: potential for inequitable access?个性化医疗与医疗保健的可及性：潜在的不公平获取？
Eur J Hum Genet. 2013 Feb;21(2):143-7. doi: 10.1038/ejhg.2012.149. Epub 2012 Jul 11.
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