低密度脂蛋白胆固醇（LDL-C）水平升高与载脂蛋白E4（ApoE4）相关，但与低密度脂蛋白受体（LDLR）基因中的rs688多态性无关。

Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene.

作者信息

Cahua-Pablo Gabriel, Cruz Miguel, Moral-Hernández Oscar Del, Leyva-Vázquez Marco A, Antúnez-Ortiz Diana L, Cahua-Pablo José A, Alarcón-Romero Luz Del Carmen, Ortuño-Pineda Carlos, Moreno-Godínez Ma Elena, Hernández-Sotelo Daniel, Flores-Alfaro Eugenia

机构信息

Clinical and Molecular Epidemiology Laboratory, UA of Chemical and Biological Sciences, Autonomous University of Guerrero, Mexico.

Biochemistry Medical Research Unit, Specialties Hospital, Medical Center Century XXI, Mexican Institute of Social Security, México, Distrito Federal.

出版信息

Clin Appl Thromb Hemost. 2016 Jul;22(5):465-70. doi: 10.1177/1076029614568714. Epub 2015 Jan 19.

DOI:10.1177/1076029614568714

PMID:25601895

Abstract

INTRODUCTION

Apolipoprotein E (ApoE) 4 isoform has been associated with elevated levels of cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs), meanwhile several polymorphisms in the LDL receptor (LDLR) gene have been associated with increased levels of total cholesterol and LDL-C.

MATERIAL AND METHODS

We studied 400 women from Southwest Mexico. Anthropometric features and biochemical profile were evaluated, and genotyping of single nucleotide polymorphisms rs429358 and rs7412 in the APOE gene and rs688 in the LDLR gene was determined by TaqMan assays.

RESULTS

We found significant association between LDL-C (odds ratio [OR] = 3.3, 95% confidence interval [CI]: 1.9-5.7) and marginal association with TG (OR = 1.7, 95% CI: 1.0-2.9) of atherogenic risk in women carriers of the ApoE4 isoform compared to ApoE3. The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C.

CONCLUSION

Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis.

摘要

引言

载脂蛋白E（ApoE）4异构体与胆固醇、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TGs）水平升高有关，同时低密度脂蛋白受体（LDLR）基因中的几种多态性与总胆固醇和LDL-C水平升高有关。

材料与方法

我们研究了来自墨西哥西南部的400名女性。评估了人体测量特征和生化指标，并通过TaqMan分析确定了APOE基因中rs429358和rs7412以及LDLR基因中rs688的单核苷酸多态性基因分型。

结果

我们发现，与ApoE3相比，携带ApoE4异构体的女性发生动脉粥样硬化风险时，LDL-C存在显著关联（优势比[OR]=3.3，95%置信区间[CI]：1.9-5.7），与TG存在边缘关联（OR=1.7，95%CI：1.0-2.9）。未发现LDLR基因中rs688的TT基因型与总胆固醇或LDL-C水平升高有关联。