Coates Laura C
NIHR Clinical Lecturer in Rheumatology, Leeds Institute of Rheumatology and Musculoskeletal Medicine, University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Curr Opin Rheumatol. 2015 Mar;27(2):107-10. doi: 10.1097/BOR.0000000000000140.
Psoriatic arthritis (PsA) is an inflammatory arthritis causing significant joint damage and impaired quality of life. A treat to target approach has revolutionized the care of patients with rheumatoid arthritis over the last decade. There is now increasing interest in a similar approach in PsA, as it seems that ongoing joint inflammation predicts subsequent damage and loss of function.
A 2011 European League Against Rheumatism review highlighted a lack of evidence for treat to target in PsA. However, with the development of the minimal disease activity criteria, a target is available and preliminary results from the first randomized treat-to target study (Tight Control of PsA Study) using these criteria have shown significant benefit in joint and skin disease activity and patient-reported outcomes.
Early evidence has shown the potential benefit of a treat-to-target approach in PsA and further research is needed to optimize treatment pathways for all subtypes of the disease.
银屑病关节炎(PsA)是一种炎症性关节炎,可导致严重的关节损伤和生活质量受损。在过去十年中,靶向治疗方法彻底改变了类风湿关节炎患者的治疗方式。目前,人们对PsA采用类似方法的兴趣日益浓厚,因为持续的关节炎症似乎预示着随后的损伤和功能丧失。
2011年欧洲抗风湿病联盟的一项综述强调,缺乏PsA靶向治疗的证据。然而,随着最小疾病活动标准的制定,有了一个目标,并且使用这些标准的第一项随机靶向治疗研究(PsA严格控制研究)的初步结果显示,在关节和皮肤疾病活动以及患者报告的结果方面有显著益处。
早期证据表明靶向治疗方法在PsA中具有潜在益处,需要进一步研究以优化该疾病所有亚型的治疗途径。