Department of Rheumatology, University of California, Los Angeles Medical Center, Los Angeles, CA, USA.
Scott & White Health Plan, Temple, TX, USA.
Clin Rheumatol. 2017 Sep;36(9):2045-2054. doi: 10.1007/s10067-017-3578-9. Epub 2017 Feb 25.
The main objective of the present study is to evaluate the misalignment between psoriatic arthritis (PsA) patient- and physician-reported satisfaction with PsA control. Data came from the Adelphi Rheumatology Disease Specific Programme, a retrospective, cross-sectional survey of US-based rheumatologists and patients. Physicians provided satisfaction and clinical characteristics on tender joint count, swollen joint count, and percent body surface area (BSA) affected by psoriasis. Patients provided data on satisfaction, the Work Productivity Activity Impairment and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires. Based on their satisfaction response, patient-physician pairs were classified into aligned (both satisfied or dissatisfied) or misaligned (rated satisfaction differently) groups. Multivariate analysis evaluated association of characteristics with misalignment. Among 305 paired patient-physician records analyzed, 23.6% were misaligned and 76.4% were aligned. The misaligned group had shorter disease duration (mean years, 5.2 vs. 6.4), used fewer biologic disease-modifying antirheumatic drugs (49.3 vs. 62.9%), had more swollen (mean, 3.7 vs. 1.9, P = 0.0002) and tender joints (mean, 5.6 vs. 2.9, P < 0.0001), greater proportion of patients with comorbidities (72.2 vs. 63.1%), and >3% BSA affected by psoriatic skin lesions (64.2 vs. 55.1%). Misaligned patients reported greater work impairment (mean, 38.7 vs. 21.4, P = 0.0004), daily activities (mean, 38.7 vs. 22.3, P < 0.0001), and higher disease burden (mean HAQ-DI; 0.56 vs. 0.37, P = 0.0001). Multivariate analysis found the number of swollen joints (P = 0.02) and HAQ-DI score (P = 0.03) was significantly associated with misalignment among all patients; however, not in the subgroup of employed patients. Patient-physician misalignment is associated with increased disease activity and disability among patients with PsA.
本研究的主要目的是评估银屑病关节炎(PsA)患者和医生报告的对疾病控制的满意度之间的差异。数据来自 Adelphi 风湿病学疾病专项计划,这是一项基于美国风湿病医生和患者的回顾性、横断面调查。医生提供了压痛关节数、肿胀关节数和受银屑病影响的体表面积百分比(BSA)的满意度和临床特征。患者提供了对满意度、工作生产力和活动障碍问卷(HAQ-DI)问卷的评价。根据他们的满意度反应,将患者-医生配对分为一致(均满意或不满意)或不一致(满意度不同)组。多变量分析评估了特征与不一致的关联。在分析的 305 对患者-医生记录中,23.6%的患者-医生配对不一致,76.4%的患者-医生配对一致。不一致组的疾病持续时间较短(平均年数,5.2 岁与 6.4 岁),使用的生物改善病情抗风湿药物较少(49.3%与 62.9%),肿胀关节更多(平均 3.7 个与 1.9 个,P=0.0002)和压痛关节更多(平均 5.6 个与 2.9 个,P<0.0001),有更多的合并症患者(72.2%与 63.1%)和受银屑病皮肤损伤影响的 BSA 超过 3%(64.2%与 55.1%)。不一致的患者报告了更大的工作障碍(平均 38.7 与 21.4,P=0.0004)、日常活动(平均 38.7 与 22.3,P<0.0001)和更高的疾病负担(平均 HAQ-DI;0.56 与 0.37,P=0.0001)。多变量分析发现,肿胀关节数(P=0.02)和 HAQ-DI 评分(P=0.03)与所有患者的不一致显著相关;然而,在就业患者亚组中并非如此。患者-医生的不一致与患有 PsA 的患者的疾病活动度和残疾增加有关。