Molina Collada Juan, Trives Laura, Castrejón Isabel
Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Open Access Rheumatol. 2021 Jul 12;13:191-200. doi: 10.2147/OARRR.S276980. eCollection 2021.
Rheumatic inflammatory diseases include a diverse and heterogeneous group of multifaceted disorders in which clinical history and physical examination are essential to make treatment choices and for optimizing outcomes. Composite outcome measures have become very relevant in rheumatology to evaluate disease activity as they capture the most important dimensions of the disease into one single measure. Most outcome measures may include disease manifestations, laboratory data, physician examination as well as the patient perspective as different outcome dimensions of the disease into a simple index. These outcome measures have proved their utility for guiding treatment in treat-to- target strategies and personalized medicine, with remission being the ultimate goal. In this narrative review, we go over the most commonly used outcome measures in rheumatoid arthritis, spondyloarthropathies, including psoriatic arthritis, and systemic lupus erythematosus to provide a practical summary for clinicians for everyday routine care.
风湿性炎症性疾病包括一组多样且异质性的多方面病症，其中临床病史和体格检查对于做出治疗选择和优化治疗结果至关重要。复合结局指标在风湿病学中对于评估疾病活动度变得非常重要，因为它们将疾病的最重要方面纳入单一指标。大多数结局指标可能包括疾病表现、实验室数据、医生检查以及患者对疾病不同结局维度的看法，将其整合为一个简单指数。这些结局指标已证明在指导达标治疗策略和个性化医疗中的效用，缓解是最终目标。在这篇叙述性综述中，我们回顾了类风湿关节炎、脊柱关节炎（包括银屑病关节炎）和系统性红斑狼疮中最常用的结局指标，为临床医生日常常规护理提供实用总结。
