Barman Malin, Jonsson Karin, Hesselmar Bill, Sandin Anna, Sandberg Ann-Sofie, Wold Agnes E
Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Acta Paediatr. 2015 Apr;104(4):405-13. doi: 10.1111/apa.12936. Epub 2015 Feb 18.
Vitamin D may be involved in allergy development, but there is conflicting evidence. We investigated if dietary intake of vitamin D and levels of 25OHD in serum differed between allergic and nonallergic adolescents and if serum 25OHD correlated with dietary intake of vitamin D or season of blood sampling.
Serum 25-hydroxy vitamin D (25OHD) levels were analysed in 13-year-old subjects with atopic eczema (n = 55), respiratory allergy (n = 55) or no allergy (n = 55). Intake of fat-containing foods was assessed by food-frequency questionnaires, and total daily vitamin D intake was calculated. Logistic regression was used to adjust for gender, parental allergy and time of blood sampling.
Subjects with atopic eczema or respiratory allergy did not differ from nonallergic controls regarding serum 25OHD levels or calculated vitamin D intake. Subjects sampled in the autumn had significantly higher levels of serum 25OHD than subjects sampled in the winter or spring. Serum 25OHD levels correlated to consumption of vitamin D-fortified lean milk (p = 0.001).
The findings suggest no association between allergy and 25OHD levels in serum or vitamin D intake in adolescents. Serum 25OHD levels correlated to intake of vitamin D-fortified lean milk.
维生素D可能参与过敏的发生发展，但证据相互矛盾。我们调查了过敏性和非过敏性青少年之间维生素D的膳食摄入量及血清25羟维生素D（25OHD）水平是否存在差异，以及血清25OHD是否与维生素D的膳食摄入量或采血季节相关。
对患有特应性皮炎（n = 55）、呼吸道过敏（n = 55）或无过敏（n = 55）的13岁受试者的血清25羟维生素D（25OHD）水平进行分析。通过食物频率问卷评估含脂肪食物的摄入量，并计算每日维生素D的总摄入量。采用逻辑回归分析对性别、父母过敏情况和采血时间进行校正。
患有特应性皮炎或呼吸道过敏的受试者与非过敏性对照组在血清25OHD水平或计算出的维生素D摄入量方面无差异。秋季采血的受试者血清25OHD水平显著高于冬季或春季采血的受试者。血清25OHD水平与维生素D强化低脂牛奶的摄入量相关（p = 0.001）。
研究结果表明青少年过敏与血清25OHD水平或维生素D摄入量之间无关联。血清25OHD水平与维生素D强化低脂牛奶的摄入量相关。
