Byun Eun Jung, Heo Jinyoung, Cho Sang Hyun, Lee Jeong Deuk, Kim Hei Sung
Department of Dermatology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Republic of Korea.
Department of Preventive Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
BMJ Open. 2017 Jul 10;7(7):e016409. doi: 10.1136/bmjopen-2017-016409.
To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level.
This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environmental factors was collected. Blood and urine samples were taken for vitamin D and cotinine, respectively. Descriptive and multivariable logistic regression was performed on the data.
South Korea (nationwide).
2515 individuals aged 10-18 years who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2011.
Vitamin D status was determined through measurement of serum 25-hydroxyvitamin D (25OHD). Smoking status was classified based on the urine cotinine level. Physician diagnosed with AD and asthma were assessed using a questionnaire.
Overall, 73.3% of the subjects were vitamin D deficient (25OHD <20 ng/mL) and 24.4% of the subjects were vitamin D insufficient (25OHD, 20-29.9 ng/mL). Older age (p<0.001), female gender (p<0.001), urban residence (p=0.019), higher body mass index (p=0.003) and sampling in winter months (November-March) (p<0.001) were independently associated with low serum 25OHD levels. With cotinine verification, 18.2% of the participants were classified as active smokers, and 43.4% were classified as passive smokers. After adjusting for potential confounders, serum 25OHD status showed no association with AD or asthma.
Vitamin D deficiency is highly prevalent in Korean adolescents. Cotinine-verified prevalence of smoking was also high, but its relationship with vitamin D deficiency was not confirmed in our study. Above all, our results provide epidemiological evidence against the association of vitamin D status with AD and asthma at the national level among Korean adolescents.
确定韩国青少年维生素D水平未达最佳状态的患病率及风险因素，并在全国范围内评估其与特应性皮炎（AD）和哮喘的关系。
这是一项横断面研究，数据来自韩国国家健康与营养检查调查。收集了社会经济特征、临床数据和环境因素等信息。分别采集血液和尿液样本检测维生素D和可替宁。对数据进行描述性和多变量逻辑回归分析。
韩国（全国范围）。
2008年至2011年参加韩国国家健康与营养检查调查的2515名10至18岁个体。
通过测量血清25-羟基维生素D（25OHD）来确定维生素D状态。根据尿液可替宁水平对吸烟状况进行分类。使用问卷评估医生诊断的AD和哮喘。
总体而言，73.3%的受试者维生素D缺乏（25OHD<20 ng/mL），24.4%的受试者维生素D不足（25OHD，20 - 29.9 ng/mL）。年龄较大（p<0.001）、女性（p<0.001）、城市居住（p=0.019）、较高的体重指数（p=0.003）以及在冬季月份（11月至3月）采样（p<0.001）与低血清25OHD水平独立相关。经可替宁验证，18.2%的参与者被归类为现吸烟者，43.4%被归类为被动吸烟者。在调整潜在混杂因素后，血清25OHD状态与AD或哮喘无关联。
维生素D缺乏在韩国青少年中非常普遍。经可替宁验证的吸烟患病率也很高，但在我们的研究中未证实其与维生素D缺乏的关系。最重要的是，我们的结果提供了流行病学证据，反对在韩国青少年全国层面上维生素D状态与AD和哮喘之间存在关联。
