Sugai-Guérios Maura Harumi, Balmant Wellington, Furigo Agenor, Krieger Nadia, Mitchell David Alexander
Departamento de Engenharia Química e Engenharia de Alimentos, Universidade Federal de Santa Catarina, Centro Tecnológico, Cx.P. 476, Florianópolis, 88040-900, Santa Catarina, Brazil.
Adv Biochem Eng Biotechnol. 2015;149:171-221. doi: 10.1007/10_2014_299.
Solid-state fermentation (SSF) with filamentous fungi is a promising technique for the production of a range of biotechnological products and has the potential to play an important role in future biorefineries. The performance of such processes is intimately linked with the mycelial mode of growth of these fungi: Not only is the production of extracellular enzymes related to morphological characteristics, but also the mycelium can affect bed properties and, consequently, the efficiency of heat and mass transfer within the bed. A mathematical model that describes the development of the fungal mycelium in SSF systems at the particle scale would be a useful tool for investigating these phenomena, but, as yet, a sufficiently complete model has not been proposed. This review presents the biological and mass transfer phenomena that should be included in such a model and then evaluates how these phenomena have been modeled previously in the SSF and related literature. We conclude that a discrete lattice-based model that uses differential equations to describe the mass balances of the components within the system would be most appropriate and that mathematical expressions for describing the individual phenomena are available in the literature. It remains for these phenomena to be integrated into a complete model describing the development of fungal mycelia in SSF systems.
丝状真菌固态发酵（SSF）是一种生产一系列生物技术产品的很有前景的技术，并且有潜力在未来的生物精炼厂中发挥重要作用。此类工艺的性能与这些真菌的菌丝体生长模式密切相关：不仅胞外酶的产生与形态特征有关，而且菌丝体还会影响床层特性，进而影响床层内的传热和传质效率。一个能够描述颗粒尺度下SSF系统中真菌菌丝体生长情况的数学模型，将是研究这些现象的有用工具，但到目前为止，尚未提出一个足够完整的模型。这篇综述介绍了此类模型应包含的生物和传质现象，然后评估了这些现象在之前的SSF及相关文献中是如何建模的。我们得出结论，基于离散晶格的模型，使用微分方程来描述系统内各组分的质量平衡，将是最合适的，并且文献中已有描述各个现象的数学表达式。仍有待将这些现象整合到一个完整的模型中，以描述SSF系统中真菌菌丝体的生长情况。
