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[肝移植术后并发症管理。通过标准化方法和跨学科合作提高患者安全性]

[Complication management after liver transplantation. Increasing patient safety by standardized approach and interdisciplinary cooperation].

作者信息

Houben P, Gotthardt D N, Radeleff B, Sauer P, Büchler M W, Schemmer P

机构信息

Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, Kirschnerstr. 1, 69120, Heidelberg, Deutschland.

出版信息

Chirurg. 2015 Feb;86(2):139-45. doi: 10.1007/s00104-014-2883-y.

DOI:10.1007/s00104-014-2883-y
PMID:25604306
Abstract

The interdisciplinary management of postoperative complications in liver transplantation is of extreme importance. Due to organ shortage and prioritization of the most severely ill recipients in the model for end-stage liver disease (MELD)-based allocation, both donor and recipient associated morbidity are increasing. An interdisciplinary, structured monitoring concept is essential for the timely identification and specific treatment of postoperative complications. Interdisciplinary clinical rounds, laboratory testing and Doppler ultrasound monitoring of the graft perfusion are as important as comprehensive anti-infection prophylaxis and immunosuppression. Arterial perfusion disorders of any kind, biliary complications and postoperative fluid accumulation demand individualized therapeutic concepts. In summary, the success of liver transplantation depends on the communication and coordinated interdisciplinary cooperation of all disciplines involved.

摘要

肝移植术后并发症的多学科管理极其重要。由于器官短缺以及在基于终末期肝病模型(MELD)的分配中优先考虑病情最严重的受者,供体和受者相关的发病率都在上升。一个多学科、结构化的监测概念对于及时识别和特异性治疗术后并发症至关重要。多学科临床查房、实验室检查以及对移植物灌注的多普勒超声监测与全面的抗感染预防和免疫抑制同样重要。任何类型的动脉灌注障碍、胆道并发症和术后积液都需要个体化的治疗方案。总之,肝移植的成功取决于所有相关学科之间的沟通和协调的多学科合作。

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本文引用的文献

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Outcomes of liver transplantation alone after listing for simultaneous kidney: comparison to simultaneous liver kidney transplantation.在列入肝肾联合移植名单后仅进行肝移植的结果:与肝肾联合移植的比较。
Transplantation. 2015 Apr;99(4):823-8. doi: 10.1097/TP.0000000000000438.
2
Effect of delayed CNI-based immunosuppression with Advagraf® on liver function after MELD-based liver transplantation [IMUTECT].基于终末期肝病模型(MELD)评分的肝移植术后使用Advagraf®进行延迟的基于钙调神经磷酸酶抑制剂(CNI)的免疫抑制对肝功能的影响[IMUTECT研究]
BMC Surg. 2014 Sep 1;14:64. doi: 10.1186/1471-2482-14-64.
3
The effect of Doppler ultrasound on early vascular interventions and clinical outcomes after liver transplantation.
Visc Med. 2017 May;33(2):106-116. doi: 10.1159/000456041. Epub 2017 Apr 13.
多普勒超声对肝移植术后早期血管干预及临床结局的影响。
World J Surg. 2014 Dec;38(12):3202-9. doi: 10.1007/s00268-014-2721-x.
4
The MELD score predicts the short-term and overall survival after liver transplantation in patients with primary sclerosing cholangitis or autoimmune liver diseases.终末期肝病模型(MELD)评分可预测原发性硬化性胆管炎或自身免疫性肝病患者肝移植后的短期和总体生存率。
Langenbecks Arch Surg. 2014 Dec;399(8):1001-9. doi: 10.1007/s00423-014-1237-z. Epub 2014 Aug 9.
5
Prediction of postoperative mortality in liver transplantation in the era of MELD-based liver allocation: a multivariate analysis.基于 MELD 评分的肝分配时代肝移植术后死亡率的预测:多变量分析。
PLoS One. 2014 Jun 6;9(6):e98782. doi: 10.1371/journal.pone.0098782. eCollection 2014.
6
Current strategies for immunosuppression following liver transplantation.肝移植后免疫抑制的当前策略。
Langenbecks Arch Surg. 2014 Dec;399(8):981-8. doi: 10.1007/s00423-014-1191-9. Epub 2014 Apr 20.
7
Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma - systematic review and meta-analysis.依维莫司治疗肝细胞癌的治疗潜力和不良事件 - 系统评价和荟萃分析。
Cancer Med. 2013 Dec;2(6):862-71. doi: 10.1002/cam4.150. Epub 2013 Oct 22.
8
Persistent ascites after liver transplantation: etiology, treatment and impact on survival.肝移植术后持续性腹水:病因、治疗及对生存的影响。
Ann Transplant. 2013 Jul 24;18:378-83. doi: 10.12659/AOT.883982.
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Incidence, risk factors and management of incisional hernia in a high volume liver transplant center.大型肝脏移植中心切口疝的发病率、危险因素及管理
Ann Transplant. 2013 May 16;18:223-30. doi: 10.12659/AOT.883914.
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Biliary complications after liver transplantation: old problems and new challenges.肝移植术后胆道并发症:老问题与新挑战。
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