Kostin V I
Farmakol Toksikol. 1989 Nov-Dec;52(6):49-52.
In acute experiments on dogs and cats with occlusion of the coronary arteries the antianginal activities of malate (100 mg/kg) and NAD (0.2 mg/kg) were studied. The drugs were found to increase the collateral blood flow and the contractile activity of the myocardium against the background of a moderate rise of the heart oxygen consumption and to normalize the systemic hemodynamics parameters.
在对冠状动脉闭塞的狗和猫进行的急性实验中，研究了苹果酸盐（100毫克/千克）和烟酰胺腺嘌呤二核苷酸（0.2毫克/千克）的抗心绞痛活性。结果发现，在心脏耗氧量适度增加的情况下，这些药物能增加侧支血流量和心肌收缩活性，并使全身血流动力学参数恢复正常。
