儿童维生素D状况与1型糖尿病：根据纬度和肤色进行评估

Vitamin D status and type 1 diabetes in children: evaluation according to latitude and skin color.

作者信息

Cadario F, Prodam F, Savastio S, Monzani A, Balafrej A, Bellomo G, Bona G

机构信息

Division of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", Novara, Italy -

出版信息

Minerva Pediatr. 2015 Jun;67(3):263-7. Epub 2015 Jan 21.

PMID:25604589

Abstract

AIM

We aim to investigate vitamin D (25OHD) levels in children with or without type 1 diabetes (T1D) according to latitude and skin color.

METHODS

We compared 25OHD levels in children with T1D living in Piedmont, of Caucasian or Moroccan origin, with healthy control subjects matched for age and ethnicity. Data of resident children in Morocco, with and without T1D, were used for comparison.

RESULTS

Caucasian (21.4±1.5 vs. 24.0±0.5 ng/mL, P<0.05) and Moroccan children with T1D (12.0±2.6 vs. 17.1±1.7 ng/mL, P<0.05) living in Piedmont had lower 25OHD levels than their counterparts without diabetes. Moroccan children living in Morocco with and without T1D had similar 25OHD levels. Vitamin D deficiency was associated with T1D in Caucasian and Moroccan children living in Piedmont (OR: 1.720, CI95% 1.034-2.860, P<0.03), CONCLUSION: Lower vitamin D levels were associated with T1D in Piedmont. Further studies are necessary to explain a possible relationship between vitamin D and T1D.

摘要

目的

我们旨在根据纬度和肤色调查1型糖尿病（T1D）患儿与非T1D患儿的维生素D（25OHD）水平。

方法

我们比较了居住在皮埃蒙特的白种人或摩洛哥裔T1D患儿与年龄和种族相匹配的健康对照者的25OHD水平。摩洛哥有T1D和无T1D的常住儿童的数据用于比较。

结果

居住在皮埃蒙特的白种人（21.4±1.5对24.0±0.5 ng/mL，P<0.05）和摩洛哥裔T1D患儿（12.0±2.6对17.1±1.7 ng/mL，P<0.05）的25OHD水平低于无糖尿病的对应儿童。居住在摩洛哥的有T1D和无T1D的摩洛哥儿童的25OHD水平相似。维生素D缺乏与居住在皮埃蒙特的白种人和摩洛哥裔儿童的T1D相关（OR：1.720，CI95% 1.034 - 2.860，P<0.03）。结论：在皮埃蒙特，较低的维生素D水平与T1D相关。有必要进行进一步研究以解释维生素D与T1D之间可能的关系。