Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Pediatr Diabetes. 2010 Aug;11(5):345-50. doi: 10.1111/j.1399-5448.2009.00589.x.
To find out whether vitamin D levels are lower in children with newly diagnosed type 1 diabetes (T1D) as compared to non-diabetic subjects.
Plasma levels of vitamin D (25-OHD) were measured by high performance liquid chromatography (HPLC) in 50 children aged between 6 and 12 yr within a week of diagnosis of T1D, and in 50 healthy children.
The mean levels of vitamin D were significantly lower in patients as compared to their controls [20.02 +/- 10.63 ng/mL (50.05 +/- 26.57 mmol/L) vs. 26.16 +/- 12.28 ng/mL (65.4 +/- 30.7 mmol/L), p-value 0.009]. Twenty-nine (58%) children in the study group were vitamin D deficient (25-OHD level < 20 ng/mL or < 50 mmol/L) as compared to only 16 (32%) in the control group. Overall, 43 (86%) diabetic and 38 (76%) healthy children were either vitamin D deficient or insufficient.
These results suggest that vitamin D levels are low at the onset of T1D, and they strongly support the need for further clinical studies to prospectively evaluate the effect of vitamin D supplementation on T1D rates in this patient population.
为了明确新诊断为 1 型糖尿病（T1D）的儿童与非糖尿病对照人群相比，维生素 D 水平是否较低。
通过高效液相色谱法（HPLC）在确诊 T1D 后一周内，对 50 名年龄在 6 至 12 岁之间的儿童及 50 名健康儿童进行血浆维生素 D（25-OHD）水平检测。
与对照组相比，患者的维生素 D 水平明显更低[20.02±10.63ng/mL（50.05±26.57μmol/L）比 26.16±12.28ng/mL（65.4±30.7μmol/L），p 值=0.009]。研究组中 29 名（58%）儿童存在维生素 D 缺乏症（25-OHD 水平<20ng/mL 或<50μmol/L），而对照组中仅有 16 名（32%）存在维生素 D 缺乏症。总体而言，43 名（86%）糖尿病儿童和 38 名（76%）健康儿童存在维生素 D 缺乏或不足。
这些结果表明，T1D 发病时维生素 D 水平较低，强烈支持进一步开展临床研究，前瞻性评估维生素 D 补充对该患者人群 T1D 发生率的影响。
