Iwane S
Nihon Shokakibyo Gakkai Zasshi. 1989 Dec;86(12):2713-20.
The effect of dietary fiber on colonic carcinogenesis was studied endoscopically in rats administered 1,2-dimethylhydrazine. Colonic tumors appeared about six weeks later in rats fed 15% cellulose diet or 40% wheat bran diet than in those fed basal diet. Furthermore, the incidence of colonic tumor was significantly lower from 23th week to 26th week in the cellulose diet group (p less than 0.01) and at 26th week in the wheat bran diet group (p less than 0.05) than in the basal diet group. However, the incidence of colonic tumors and the mean number of tumors per rat at sacrifice (30th week) were not significantly different between these two high-fiber diet groups and the basal diet group. These two diets significantly increased feces 3 to 4 times in weight and 5 times in volume over the base diet. However, 15% pectin diet could neither inhibit colonic carcinogenesis nor increase the fecal weight. These results suggested that cellulose and some dietary fibers of wheat bran were effective to retard colonic carcinogenesis, and that the increased fecal weight and volume by fibers may be involved in the inhibitory effect.
在给大鼠注射1,2 - 二甲基肼后，通过内镜研究膳食纤维对结肠癌发生的影响。与喂食基础饮食的大鼠相比，喂食15%纤维素饮食或40%麦麸饮食的大鼠结肠肿瘤大约在六周后出现。此外，纤维素饮食组在第23周和第26周（p小于0.01）以及麦麸饮食组在第26周（p小于0.05）时结肠肿瘤的发生率显著低于基础饮食组。然而，在处死时（第30周），这两种高纤维饮食组与基础饮食组之间的结肠肿瘤发生率和每只大鼠的平均肿瘤数量没有显著差异。这两种饮食使粪便重量比基础饮食增加了3至4倍，体积增加了5倍。然而，15%果胶饮食既不能抑制结肠癌发生，也不能增加粪便重量。这些结果表明，纤维素和麦麸中的一些膳食纤维对延缓结肠癌发生有效，并且纤维增加粪便重量和体积可能与这种抑制作用有关。
