胃食管反流病对哮喘和慢性阻塞性肺疾病患者咳嗽相关生活质量及疾病状态的真实世界影响。

Real-world effect of gastroesophageal reflux disease on cough-related quality of life and disease status in asthma and COPD.

作者信息

Shirai Toshihiro, Mikamo Masashi, Tsuchiya Tomoyoshi, Shishido Yuichiro, Akita Takefumi, Morita Satoru, Asada Kazuhiro, Fujii Masato, Suda Takafumi

机构信息

Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.

Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.

出版信息

Allergol Int. 2015 Jan;64(1):79-83. doi: 10.1016/j.alit.2014.08.001. Epub 2014 Oct 22.

DOI:10.1016/j.alit.2014.08.001

PMID:25605530

Abstract

BACKGROUND

Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and often coexists with asthma or chronic obstructive pulmonary disease (COPD); however, it is unknown whether there are differences in the effect of GERD on these diseases. The purpose of this study was to assess the difference in the effect of GERD on cough-related quality of life and disease status in asthma and COPD in a real-world setting.

METHODS

Subjects were 132 patients with overall controlled asthma and 102 patients with stable COPD. They completed the frequency scale for symptoms of GERD (FSSG), a validated Japanese questionnaire for GERD, the Leicester Cough Questionnaire (LCQ), and the Asthma Control Test (ACT) or COPD assessment test (CAT) questionnaires.

RESULTS

We found that 29 (22.0%) patients with asthma and 22 (21.6%) patients with COPD had GERD. There was no difference in the FSSG scale between the diseases. The patients with GERD, regardless of having asthma or COPD, had lower LCQ scores affecting all health domains and lower ACT or higher CAT scores than those without GERD. Overall, the patients with COPD had lower LCQ scores regardless of the presence or absence of GERD. The FSSG scale was negatively correlated with the LCQ total score in asthma and in COPD. In contrast, the FSSG scale was positively correlated with the CAT score but not with the ACT score.

CONCLUSIONS

Patients with GERD had impaired cough-related quality of life, poor asthma control or more symptoms and impacts of COPD.

摘要

背景

胃食管反流病（GERD）是慢性咳嗽最常见的病因之一，且常与哮喘或慢性阻塞性肺疾病（COPD）共存；然而，GERD对这些疾病的影响是否存在差异尚不清楚。本研究的目的是在真实世界环境中评估GERD对哮喘和COPD患者咳嗽相关生活质量及疾病状态影响的差异。

方法

研究对象为132例总体病情得到控制的哮喘患者和102例稳定期COPD患者。他们完成了GERD症状频率量表（FSSG），这是一份经过验证的日本GERD问卷、莱斯特咳嗽问卷（LCQ）以及哮喘控制测试（ACT）或COPD评估测试（CAT）问卷。

结果

我们发现29例（22.0%）哮喘患者和22例（21.6%）COPD患者患有GERD。两种疾病在FSSG量表上无差异。患有GERD的患者，无论患有哮喘还是COPD，与未患GERD的患者相比，其LCQ评分在所有健康领域均较低，ACT评分较低或CAT评分较高。总体而言，无论是否患有GERD，COPD患者的LCQ评分均较低。在哮喘和COPD中，FSSG量表与LCQ总分呈负相关。相反，FSSG量表与CAT评分呈正相关，但与ACT评分无关。