胃食管反流病与哮喘控制和生活质量的相关性：来自中低收入国家的横断面研究。
Correlation of gastro-esophageal reflux disease with asthma control and quality of life: a cross-sectional study from a low-middle income country.
机构信息
Department of Medicine, Jinnah Medical and Dental College, Karachi, Pakistan.
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Aga Khan University, 75300 Stadium Road Karachi, Pakistan.
出版信息
Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241297879. doi: 10.1177/17534666241297879.
BACKGROUND
Gastro-esophageal reflux disease (GERD) is a chronic disease that coexists with asthma and is often responsible for repeated exacerbations, as well as has a negative impact on the quality of life (QoL). However, from our continent, there is limited data available on the exact prevalence of GERD in asthma and its association with asthma control and QoL.
OBJECTIVE
To determine the prevalence of GERD in asthma and see its association with asthma control and QoL.
DESIGN
A prospective, cross-sectional study was conducted over 8 months from September 2020 to April 2021.
METHODS
Patients with a confirmed diagnosis of asthma aged 18 years and above were recruited from the outpatient department of pulmonology. Patients' GERD score was calculated using the FSSG SCALE (Frequency Scale for Symptoms of GERD) questionnaire and the Asthma Control Test (ACT) was used to determine asthma control. To assess the QoL, the short form of health survey (SF-36) questionnaire was used. Patients were recruited through a convenience sampling technique.
RESULTS
A total of 190 patients were enrolled, the mean age was 33.7 ± 13.3 years and 55.8% were female. Prevalence of GERD was (136) 71.6%. According to the ACT score, 81 (42.6%) patients had very poorly controlled asthma (mean GERD score of 13.73 ± 7.66), compared to 59 (31.1%) asthmatic patients who had well-controlled asthma (mean GERD score of 11.97 ± 7.39, = 0.43). SF-36 questionnaire was used to measure QoL showed GERD patients had statistically lower scores in the following domains of QoL: "Role Limitations due to Physical Functioning" (37.78 vs 57.44, = 0.003), "Energy/Fatigue" (47.47 vs 55.07, = 0.02), and "Bodily Pain" (63.40 vs 72.84, = 0.01).
CONCLUSION
This study showed a high prevalence of GERD among asthmatic patients with a negative impact on QoL but did not demonstrate a statistically significant relationship between GERD and asthma control.
背景
胃食管反流病（GERD）是一种慢性疾病，与哮喘共存，常导致哮喘反复发作，并对生活质量（QoL）产生负面影响。然而，在我们所在的大洲，有关哮喘中 GERD 的确切患病率及其与哮喘控制和 QoL 的关系的数据有限。
目的
确定哮喘中 GERD 的患病率，并观察其与哮喘控制和 QoL 的关系。
设计
这是一项前瞻性、横断面研究，于 2020 年 9 月至 2021 年 4 月进行了 8 个月。
方法
从呼吸科门诊招募了确诊为哮喘的 18 岁及以上的患者。使用 FSSG SCALE（GERD 症状频率量表）问卷计算患者的 GERD 评分，使用哮喘控制测试（ACT）确定哮喘控制情况。使用健康调查简表（SF-36）问卷评估 QoL。通过方便抽样技术招募患者。
结果
共纳入 190 例患者，平均年龄为 33.7±13.3 岁，55.8%为女性。GERD 的患病率为（136）71.6%。根据 ACT 评分，81 例（42.6%）患者哮喘控制极差（平均 GERD 评分为 13.73±7.66），而 59 例（31.1%）哮喘控制良好的患者哮喘控制良好（平均 GERD 评分为 11.97±7.39， = 0.43）。使用 SF-36 问卷测量 QoL 显示，GERD 患者在以下 QoL 领域的评分较低：“因身体机能受限的角色限制”（37.78 对 57.44， = 0.003）、“精力/疲劳”（47.47 对 55.07， = 0.02）和“躯体疼痛”（63.40 对 72.84， = 0.01）。
结论
本研究显示哮喘患者中 GERD 患病率较高，对 QoL 产生负面影响，但未显示 GERD 与哮喘控制之间存在统计学显著关系。
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