Grandes Xavier A, Talanki Manjunatha Ramya, Habib Salma, Sangaraju Sai Lahari, Yepez Daniela
Research, Universidad Catolica Santiago de Guayaquil, Guayaquil, ECU.
Internal Medicine, Kempegowda Institute of Medical Sciences, Bangalore, IND.
Cureus. 2022 May 11;14(5):e24917. doi: 10.7759/cureus.24917. eCollection 2022 May.
Gastroesophageal reflux disease (GERD) is defined by retrograde reflux of gastric contents to the esophagus leading to various signs and symptoms that range from heartburn/regurgitation to the development of extraesophageal respiratory syndromes like asthma. Although a cause-effect relationship has been proposed, evidence suggests that these two entities share a complex mechanism that may be reciprocal to each other. The understanding of the underlying mechanisms is imperial due to the fact that asthmatic patients may benefit from reflux therapy with subsequent improvement in pulmonary function testing and quality of life. This study has revised available literature in order to provide evidence for a nexus between GERD and asthma based on clinical correlation, pathophysiology, and pharmacologic management.
胃食管反流病（GERD）的定义是胃内容物逆行反流至食管，导致从烧心/反流到哮喘等食管外呼吸综合征等各种体征和症状。尽管有人提出了因果关系，但证据表明，这两种疾病具有复杂的机制，可能相互影响。由于哮喘患者可能从反流治疗中受益，从而改善肺功能测试结果和生活质量，因此了解潜在机制至关重要。本研究回顾了现有文献，以便基于临床相关性、病理生理学和药物治疗，为GERD与哮喘之间的联系提供证据。
