子宫内膜干细胞的再生潜能：一篇综述
Regenerative potential of endometrial stem cells: a mini review.
作者信息
Ghobadi Farnaz, Mehrabani Davood, Mehrabani Golnoush
机构信息
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
World J Plast Surg. 2015 Jan;4(1):3-8.
Abstract
Recent findings in stem cell biology have opened a new window in regenerative medicine. The endometrium possesses mesenchymal stem cells (MSCs) called endometrial stem cells (EnSCs) having specific regenerative properties linked to adult stem cells. They contribute in tissue remodeling and engineering and were shown to have immuno-modulating effects. Many clinical trials were undertaken to ascertain the therapeutic potential of EnSCS. In this mini review, we showed that EnSCs are readily available sources of adult stem cells in the uterus that can be highlighted for their renewable multipotent and differentiation properties. This cell population may be a practical solution of choice in reproductive biology, regenerative medicine and autologous stem cell therapy.
摘要
干细胞生物学的最新研究成果为再生医学打开了一扇新窗口。子宫内膜拥有被称为子宫内膜干细胞（EnSCs）的间充质干细胞（MSCs），这些细胞具有与成体干细胞相关的特定再生特性。它们有助于组织重塑和工程构建，并已证明具有免疫调节作用。许多临床试验已开展以确定子宫内膜干细胞的治疗潜力。在本综述中，我们表明子宫内膜干细胞是子宫中易于获取的成体干细胞来源，因其可再生的多能性和分化特性而值得关注。这一细胞群体可能是生殖生物学、再生医学和自体干细胞治疗中一个切实可行的选择方案。
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