Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell Tissue Res. 2021 May;384(2):241-254. doi: 10.1007/s00441-021-03419-6. Epub 2021 Mar 2.
Endometrial-related disorders including Asherman's syndrome, thin endometrium, pelvic organ prolapse, and cesarean scar pregnancies can be accompanied by different symptoms such as amenorrhea, infertility, abnormal placental implantation and recurrent miscarriage. Different methods have been introduced to overcome these problems such as surgery and hormonal therapy but none of them has shown promising outcomes. On the other hand, the development of novel regenerative therapeutic strategies has opened new avenues for the treatment of endometrial-related deficiencies. In this regard, different types of scaffolds, acellular matrices and also cell therapy with adult or stem cells have been investigated for the treatment of endometrial-related deficiencies. In this paper, we review the current status of cell-based endometrium regeneration using scaffold dependent and scaffold-free methods and future perspectives in this field. Moreover, we discuss the endometrial diseases that can be candidates for cell-based treatments. Also, the cells with the potential for endometrial regeneration are explained.
子宫内膜相关疾病包括 Asherman 综合征、薄型子宫内膜、盆腔器官脱垂和剖宫产瘢痕妊娠，可伴有不同症状，如闭经、不孕、胎盘植入异常和复发性流产。已经引入了不同的方法来克服这些问题，如手术和激素治疗，但没有一种方法显示出有希望的结果。另一方面，新型再生治疗策略的发展为子宫内膜相关缺陷的治疗开辟了新途径。在这方面，已经研究了不同类型的支架、去细胞基质以及用成体或干细胞进行细胞治疗，以治疗子宫内膜相关缺陷。本文综述了基于支架和无支架的细胞子宫内膜再生的现状以及该领域的未来展望。此外，我们还讨论了可作为细胞治疗候选的子宫内膜疾病。还解释了具有子宫内膜再生潜力的细胞。
