Akao Makoto, Abe Ryusuke, Sato Noriko, Hasegawa-Tanigome Atsuko, Kumagai Hitoshi, Kumagai Hitomi
Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
Department of Food Business, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan.
Int J Mol Sci. 2015 Jan 19;16(1):2117-29. doi: 10.3390/ijms16012117.
Phytate-removed and deamidated soybean β-conglycinin (PrDS) prepared by ion-exchange resins was supplemented to be 4% in the diet administered to ovariectomized rats to investigate its preventive effect on osteoporosis. The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein. On the other hand, administration of PrDS restored the calcium absorption rate to the same level as the sham group. Markers of bone resorption, such as serum parathyroid hormone (PTH) and urinary deoxypyridinoline (DPD), increased, and the bone mineral density and breaking stress decreased following ovariectomy. However, PrDS supplementation suppressed the changes caused by the decrease in calcium absorption from the small intestine. Therefore, PrDS supplementation shows promise for the prevention of postmenopausal osteoporosis.
用离子交换树脂制备的植酸去除和脱酰胺大豆β-伴大豆球蛋白（PrDS），在给去卵巢大鼠的饮食中补充至4%，以研究其对骨质疏松症的预防作用。去卵巢后表观钙吸收率下降，口服去除植酸的大豆β-伴大豆球蛋白（PrS）或酪蛋白不能使其恢复。另一方面，给予PrDS可使钙吸收率恢复到与假手术组相同的水平。去卵巢后，骨吸收标志物如血清甲状旁腺激素（PTH）和尿脱氧吡啶啉（DPD）升高，骨矿物质密度和断裂应力降低。然而，补充PrDS可抑制因小肠钙吸收减少引起的变化。因此，补充PrDS有望预防绝经后骨质疏松症。
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