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本文引用的文献

1
The gut microbiota, bacterial metabolites and colorectal cancer.肠道微生物群、细菌代谢物与结直肠癌。
Nat Rev Microbiol. 2014 Oct;12(10):661-72. doi: 10.1038/nrmicro3344. Epub 2014 Sep 8.
2
Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications.系统评价：肠道微生物群在化疗或放疗引起的胃肠道黏膜炎中的作用——当前证据及潜在临床应用
Aliment Pharmacol Ther. 2014 Sep;40(5):409-21. doi: 10.1111/apt.12878. Epub 2014 Jul 11.
3
Trial Watch: DNA vaccines for cancer therapy.试验观察：用于癌症治疗的 DNA 疫苗。
Oncoimmunology. 2014 Jan 1;3(1):e28185. doi: 10.4161/onci.28185. Epub 2014 Apr 1.
4
Infection, antibiotic therapy and risk of colorectal cancer: a nationwide nested case-control study in patients with Type 2 diabetes mellitus.感染、抗生素治疗与结直肠癌风险：一项针对2型糖尿病患者的全国性巢式病例对照研究。
Int J Cancer. 2014 Aug 15;135(4):956-67. doi: 10.1002/ijc.28738. Epub 2014 Mar 21.
5
Microbial dysbiosis is associated with human breast cancer.微生物群落失调与人类乳腺癌有关。
PLoS One. 2014 Jan 8;9(1):e83744. doi: 10.1371/journal.pone.0083744. eCollection 2014.
6
Impact of pelvic radiotherapy on gut microbiota of gynecological cancer patients revealed by massive pyrosequencing.大规模焦磷酸测序揭示盆腔放疗对妇科癌症患者肠道微生物群的影响。
PLoS One. 2013 Dec 18;8(12):e82659. doi: 10.1371/journal.pone.0082659. eCollection 2013.
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Colonization of the human gut by E. coli and colorectal cancer risk.人类肠道中大肠杆菌的定植与结直肠癌风险。
Clin Cancer Res. 2014 Feb 15;20(4):859-67. doi: 10.1158/1078-0432.CCR-13-1343. Epub 2013 Dec 13.
8
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.肠道微生物群调节环磷酰胺的抗癌免疫作用。
Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537.
9
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.共生菌通过调节肿瘤微环境来控制癌症对治疗的反应。
Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.
10
The gut microbiome modulates colon tumorigenesis.肠道微生物组调节结肠肿瘤发生。
mBio. 2013 Nov 5;4(6):e00692-13. doi: 10.1128/mBio.00692-13.

癌症与肠道微生物群：一个意想不到的联系。

Cancer and the gut microbiota: an unexpected link.

作者信息

Zitvogel Laurence, Galluzzi Lorenzo, Viaud Sophie, Vétizou Marie, Daillère Romain, Merad Miriam, Kroemer Guido

机构信息

Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. INSERM, U1015, CICBT507, F-94805 Villejuif, France.

Gustave Roussy Comprehensive Cancer Center, F-94805 Villejuif, France. Equipe 11 Labellisée par la Ligue Nationale Contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. INSERM, U1138, F-75006 Paris, France.

出版信息

Sci Transl Med. 2015 Jan 21;7(271):271ps1. doi: 10.1126/scitranslmed.3010473.

DOI:10.1126/scitranslmed.3010473
PMID:25609166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4690201/
Abstract

Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor progression and how manipulations of the gut microbiota might improve the clinical activity of anticancer agents.

摘要

肠道微生物群、肠上皮和宿主免疫系统之间相互作用的变化与包括癌症在内的许多疾病有关。我们讨论了环境因素如何在肿瘤发生和肿瘤进展过程中影响这种相互作用，以及对肠道微生物群的调控如何可能改善抗癌药物的临床活性。