血清对氧磷酶活性与热烧伤的关系。
Relationship of serum paraoxonase enzyme activity and thermal burn injury.
作者信息
Yildirim Serap, Doganay Songul, Yildirim Abdulkadir, Aydin Osman Enver, Karakoc Akar, Laloglu Esra
机构信息
Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
出版信息
Eurasian J Med. 2012 Dec;44(3):153-6. doi: 10.5152/eajm.2012.36.
OBJECTIVE
This study investigated changes in serum oxidative stress parameters in burn cases compared to healthy controls.
MATERIALS AND METHODS
This study was performed in 41 burn patients with mild to severe thermal burn injuries and 38 healthy volunteers. The burn cases were selected from patients who were hospitalized in the burn unit for the treatment of second- and third-degree burns. Malondialdehyde (MDA) levels and PON-1 paraoxonase and arylesterase activities were measured in patient serum samples.
RESULTS
PON-1 paraoxonase activity and MDA levels in patients with major thermal burn injury were significantly higher than healthy controls, but PON-1 arylesterase activities were lower. A significant negative correlation was observed between the burn percentage of the total body surface area and the PON-1 arylesterase activities in patients.
CONCLUSION
Human thermal burn injury was associated with an increase in MDA production and a decrease in PON-1 arylesterase activity, which was proportional to the percentage of total burned surface area.
目的
本研究调查了烧伤患者与健康对照者血清氧化应激参数的变化。
材料与方法
本研究纳入了41例轻至重度热烧伤患者和38名健康志愿者。烧伤病例选自因二度和三度烧伤在烧伤科住院治疗的患者。检测患者血清样本中的丙二醛（MDA）水平以及对氧磷酶-1（PON-1）对氧磷酶和芳基酯酶活性。
结果
重度热烧伤患者的PON-1对氧磷酶活性和MDA水平显著高于健康对照者，但PON-1芳基酯酶活性较低。患者全身表面积烧伤百分比与PON-1芳基酯酶活性之间存在显著负相关。
结论
人体热烧伤与MDA生成增加及PON-1芳基酯酶活性降低有关,且这与烧伤总面积百分比成正比。
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