Ovadia Yaniv S, Gefel Dov, Turkot Svetlana, Aharoni Dorit, Fytlovich Shlomo, Troen Aron M
Department of Internal Medicine "C", Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel ; Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.
Endocrinology Clinic, Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel.
J Thyroid Res. 2014;2014:913672. doi: 10.1155/2014/913672. Epub 2014 Dec 14.
Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (n = 17), hypothyroidism (n = 14), or control (n = 31), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., P < 0.05). Mean estimated iodine intake was significantly lower in the NNG group (65 ± 30 μg/d) than in controls (115 ± 60 μg/d) (P < 0.05) with intermediate intake in the hypothyroid group (73 ± 38 μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.
背景。碘摄入量信息对于预防甲状腺疾病至关重要。碘摄入不足会导致甲状腺疾病，包括非毒性结节性甲状腺肿（NNG）。目的。评估以色列地中海沿岸成年居民的碘摄入量，并探讨其与甲状腺疾病的相关性，在该地区，贫碘淡化水已成为主要饮用水源。方法。对就诊于阿什凯隆巴齐莱医疗中心的患者进行横断面研究。参与者被分为NNG组（n = 17）、甲状腺功能减退组（n = 14）或对照组（n = 31），提供血清甲状腺球蛋白（Tg）并完成半定量碘食物频率问卷。结果。NNG组血清Tg值升高（Tg > 60 ng/mL）的发生率显著高于其他组（分别为29%，而甲状腺功能减退组和对照组为7%和0%，P < 0.05）。NNG组的平均估计碘摄入量（65 ± 30 μg/d）显著低于对照组（115 ± 60 μg/d）（P < 0.05），甲状腺功能减退组的摄入量处于中间水平（73 ± 38 μg/d）。结论。在以色列阿什凯隆地区的成年患者中，血清Tg值升高和膳食碘摄入量低与NNG有关。需要开展更大规模的研究以扩展这些重要的初步发现。
