Carvalho L S
Rev Port Cardiol. 1989 Feb;8(2):121-7.
To understand physiopathology of contractibility in heart failure is needed the previous knowledge of normal muscle contractibility, calcium regulation, methods of assessment of isolated cardiac muscle and in situ heart contraction. Models of calcium movements during rest and contraction are presented and concepts of preload, afterload, Vmax and Po introduced. The importance of assessment of cardiac diastolic function is referred. Biochemical alterations in the failing myocardium are presented.
要了解心力衰竭中收缩性的病理生理学，需要先掌握正常肌肉收缩性、钙调节、离体心肌评估方法以及原位心脏收缩的相关知识。文中介绍了静息和收缩期间钙运动的模型，并引入了前负荷、后负荷、最大速度（Vmax）和最大张力（Po）的概念。文中还提及了评估心脏舒张功能的重要性。文中介绍了衰竭心肌中的生化改变。
