Dong Rui, Zheng Shan
Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China; Key Laboratory of Neonatal Disease, Ministry of Health, Shanghai, China.
J Gastroenterol Hepatol. 2015 Jun;30(6):970-6. doi: 10.1111/jgh.12900.
Biliary atresia (BA) is characterized by periductular inflammation and fibrosis and is associated with the progressive obliteration of the bile ducts. The induction and maintenance of systemic and local inflammatory responses plays a pivotal role in this process. Interleukin-8 (IL-8) is an important mediator of inflammation and the immune response in human disease. IL-8 is overexpressed in BA, and its expression positively correlates with inflammation and liver fibrosis. In this review, we focus on the available evidence, recent insights, and future clinical and preclinical possibilities regarding the role of IL-8 in BA.
胆道闭锁（BA）的特征是胆管周围炎症和纤维化，并与胆管的进行性闭塞有关。全身和局部炎症反应的诱导和维持在这一过程中起关键作用。白细胞介素-8（IL-8）是人类疾病中炎症和免疫反应的重要介质。IL-8在BA中过度表达，其表达与炎症和肝纤维化呈正相关。在本综述中，我们关注关于IL-8在BA中的作用的现有证据、最新见解以及未来临床和临床前的可能性。
