Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK.
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK.
Neuron. 2015 Jan 21;85(2):418-28. doi: 10.1016/j.neuron.2014.12.033.
Learning induces plasticity in neuronal networks. As neuronal populations contribute to multiple representations, we reasoned plasticity in one representation might influence others. We used human fMRI repetition suppression to show that plasticity induced by learning another individual's values impacts upon a value representation for oneself in medial prefrontal cortex (mPFC), a plasticity also evident behaviorally in a preference shift. We show this plasticity is driven by a striatal "prediction error," signaling the discrepancy between the other's choice and a subject's own preferences. Thus, our data highlight that mPFC encodes agent-independent representations of subjective value, such that prediction errors simultaneously update multiple agents' value representations. As the resulting change in representational similarity predicts interindividual differences in the malleability of subjective preferences, our findings shed mechanistic light on complex human processes such as the powerful influence of social interaction on beliefs and preferences.
学习会引起神经元网络的可塑性。由于神经元群体对多种表现形式都有贡献，我们推断一种表现形式的可塑性可能会影响其他形式。我们使用人类 fMRI 重复抑制来表明，学习他人价值观所引起的可塑性会影响内侧前额叶皮层（mPFC）中自身的价值表现，这种可塑性在偏好转移中也表现出明显的行为变化。我们表明，这种可塑性是由纹状体的“预测误差”驱动的，它反映了另一个人的选择与主体自身偏好之间的差异。因此，我们的数据强调了 mPFC 对主观价值的独立于主体的表现形式进行编码，从而使得预测误差同时更新多个主体的价值表现形式。由于代表性相似性的变化预测了个体间主观偏好的可塑性关系的差异，我们的研究结果为复杂的人类过程提供了机制上的解释，例如社会互动对信念和偏好的强大影响。
