Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom.
Int J Cancer. 2016 Jan 1;138(1):30-44. doi: 10.1002/ijc.29447. Epub 2015 Feb 6.
The tumour microenvironment plays an essential role in the development and spread of cancers. Tumour cells interact with the surrounding extracellular matrix (ECM), embedded within which, are a variety of non-cancer cells including cells of the vasculature, immune system and fibroblasts. The essential role of fibroblasts in the cultivation and maintenance of an environment in which tumour cells are able to maintain their aggressive phenotypic traits is becoming increasingly well documented. Cancer-associated fibroblasts are able to secrete a vast array of ECM-modulating factors, meaning that they have potential for a functional role in every step of the carcinogenic process. In particular, they are likely to have a role in early tumour-initiating inflammatory events, and so may provide a potential target for chemopreventive intervention. This review summarises the known interactions between lung tumour cells and surrounding reactive fibroblasts, highlighting the need to further investigate cancer-associated fibroblasts as therapeutic targets in lung cancer chemoprevention strategies.
肿瘤微环境在癌症的发展和扩散中起着至关重要的作用。肿瘤细胞与周围的细胞外基质（ECM）相互作用，其中嵌入着各种非癌细胞，包括血管细胞、免疫系统细胞和成纤维细胞。成纤维细胞在培养和维持肿瘤细胞能够维持其侵袭性表型特征的环境中的重要作用越来越被充分记录。癌症相关成纤维细胞能够分泌大量的 ECM 调节因子，这意味着它们在致癌过程的每一个步骤中都具有潜在的功能作用。特别是，它们可能在早期肿瘤起始的炎症事件中发挥作用，因此可能成为化学预防干预的潜在靶点。这篇综述总结了肺肿瘤细胞与周围反应性成纤维细胞之间已知的相互作用，强调了需要进一步研究癌症相关成纤维细胞作为肺癌化学预防策略中的治疗靶点。
